3-[4-(2-dimethylamino-ethoxy)-phenyl]-propionic acid | 100619-09-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-[4-(2-dimethylamino-ethoxy)-phenyl]-propionic acid
• 英文别名: 3-[4-(2-Dimethylamino-aethoxy)-phenyl]-propionsaeure；3-[4-[2-(Dimethylazaniumyl)ethoxy]phenyl]propanoate
• CAS: 100619-09-8
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: NIALLOYSNYDZMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ZGN-256 、 3-[4-(2-dimethylamino-ethoxy)-phenyl]-propionic acid 在 4-二甲氨基吡啶 、 特戊醛 、 N,N-二异丙基乙胺 作用下， 以 正庚烷 为溶剂， 以24%的产率得到
  参考文献：
  名称：

  [EN] FUMIGILLOL TYPE COMPOUNDS AND METHODS OF MAKING AND USING SAME
  [FR] COMPOSÉS DE TYPE FUMAGILLOL, LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION

  摘要：

  该披露提供了富马吉洛尔类化合物及其在治疗医学疾病（如肥胖症）中的用途。还提供了药物组合物和使用方法，例如在治疗肥胖症方面的用途。

  公开号：

  WO2013169860A1
• 作为产物：
  描述：

  对羟基苯丙酸乙酯 在 sodium ethanolate 作用下， 生成 3-[4-(2-dimethylamino-ethoxy)-phenyl]-propionic acid
  参考文献：
  名称：

  The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

  摘要：

  We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

  DOI：

  10.1007/bf02886269

文献信息

• Fumigillol compounds and methods of making and using same
  申请人：Zafgen, Inc.

  公开号：US10220015B2

  公开（公告）日：2019-03-05

  The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.

  本公开提供了烟曲霉素类化合物及其在治疗肥胖症等疾病中的用途。提供了药物组合物和使用方法，例如治疗肥胖症的方法。
• FUMIGILLOL TYPE COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：EP2850079B1

  公开（公告）日：2018-05-02
• FUMIGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：US20150126489A1

  公开（公告）日：2015-05-07

  The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
• US9573918B2
  申请人：——

  公开号：US9573918B2

  公开（公告）日：2017-02-21
• US9895339B2
  申请人：——

  公开号：US9895339B2

  公开（公告）日：2018-02-20