(1S,7R)-4-(2-hydroxyethyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (1S,7R)-4-(2-hydroxyethyl)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.23
• InChiKey: WUNGPAHZQWNPEL-QPIHLSAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Group transfer polymerization for the production of functional monomers
  申请人：Colorado State University Research Foundation

  公开号：US11286340B2

  公开（公告）日：2022-03-29

  The present invention provides efficient processes for preparing brush polymers. In general, the process comprises three distinct reaction steps utilizing two separate catalysts. In the first step, the initiating compound comprising norbornene is contacted with a silane in the presence of a catalyst, thereby forming a silated intermediate. This silated intermediate is then contacted with a monomer in the presence of a catalyst via Group Transfer Polymerization (GTP). The resulting compound from GTP is contacted with a ring opening metathesis polymerization (ROMP) catalyst to prepare the brush polymer. Surprisingly, the brush polymers obtained from the above process are accessed in an efficient and rapid GTP methodology as compared to prior methods.

  本发明提供了制备刷状聚合物的高效工艺。一般来说，该工艺包括三个不同的反应步骤，分别使用两种催化剂。在第一步中，包含降冰片烯的引发化合物在催化剂存在下与硅烷接触，从而形成硅化中间体。然后，在催化剂存在下，通过基团转移聚合（GTP）将硅化中间体与单体接触。将 GTP 生成的化合物与开环偏聚（ROMP）催化剂接触，制备刷状聚合物。令人惊奇的是，与之前的方法相比，上述工艺可通过高效、快速的 GTP 方法获得刷状聚合物。
• GROUP TRANSFER POLYMERIZATION FOR THE PRODUCTION OF FUNCTIONAL MONOMERS
  申请人：Colorado State University Research Foundation

  公开号：US20200239626A1

  公开（公告）日：2020-07-30

  The present invention provides efficient processes for preparing brush polymers. In general, the process comprises three distinct reaction steps utilizing two separate catalysts. In the first step, the initiating compound comprising norbornene is contacted with a silane in the presence of a catalyst, thereby forming a silated intermediate. This silated intermediate is then contacted with a monomer in the presence of a catalyst via Group Transfer Polymerization (GTP). The resulting compound from GTP is contacted with a ring opening metathesis polymerization (ROMP) catalyst to prepare the brush polymer. Surprisingly, the brush polymers obtained from the above process are accessed in an efficient and rapid GTP methodology as compared to prior methods.