6-羟基萘-1,2-二酮 | 607-20-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 6-羟基萘-1,2-二酮
• 中文别名: 6-羟基-1,2-萘二酮
• 英文名称: hydroxy-6 naphthoquinone-1,2
• 英文别名: 6-hydroxy-[1,2]naphthoquinone；6-Hydroxy-[1,2]naphthochinon；6-hydroxy-1,2-naphthalenedione；6-hydroxy-1,2-naphthoquinone；6-Hydroxy-1,2-naphthochinon；6-Hydroxy-1,2-naphthoquinon；1,2-Naphthalenedione, 6-hydroxy-；6-hydroxynaphthalene-1,2-dione
• CAS: 607-20-5
• 化学式: C₁₀H₆O₃
• 分子量: 174.156
• InChiKey: CQWXLWDPFSPVHK-UHFFFAOYSA-N

物化性质

• 熔点：
  165 °C (decomp)
• 沸点：
  405.2±45.0 °C(Predicted)
• 密度：
  1.439±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2914690090

反应信息

• 作为反应物：
  描述：

  6-羟基萘-1,2-二酮 、 硫酸二甲酯 生成 1,2,6-三甲氧基萘
  参考文献：
  名称：

  Synthesis and pharmacology of some 2-aminotetralins. Dopamine receptor agonists

  摘要：

  A series of 2-amino-1,2,3,4-tetrahydronaphthalene compounds bearing substituents on the nitrogen and in the aromatic ring was synthesized from beta-tetralone intermediates. Compounds were screened in vivo for dopaminergic activity using tests in which apomorphine was especially active. It was found that apparent dopaminergic activity is inherent in 2-dialkylaminotetralins, the dipropylamine substitution being the most consistently productive amine group studies. Activity was greatly enhanced by proper substitution in the aromatic ring. The 5,6-dihydroxy group was the best potentiating group found. These data support the idea that the extended conformation for the phenylethylamine moiety of ampmorphine and dopamine is favorable for dopaminergic agonist activity. They also suggest that an unetherified catechol group may not be essential for such activity.

  DOI：

  10.1021/jm00238a008
• 作为产物：
  描述：

  2,6-萘二酚 在 甲醇 、 potassium nitrososulfonate 作用下， 生成 6-羟基萘-1,2-二酮
  参考文献：
  名称：

  Teuber; Goetz, Chemische Berichte, 1954, vol. 87, p. 1236,1250

  摘要：

  DOI：

文献信息

• Réactivité du superoxyde de Potassium en phase hétérogéne: Oxydation de naphtalénedios en naphtoquinones hydroxylées
  作者：Martine De Min、Sylvie Croux、Cécile Tournaire、Michel Hocquaux、Bernard Jackquet、Esther Oliveros、Marie-Thérèse Maurette

  DOI：10.1016/s0040-4020(01)88511-2

  日期：1992.1

  Oxidation of dihydronaphthalenes by potassium superoxide (KO2) in heterogeneous aprotic media yields mono- or dihydroxynaphthoquinones, depending on the relative position of the hydroxy groups on the naphthalene moiety. The reaction proceeds mainly at the solid-liquid interface and naphthoquinones can be obtained with good yields.

  在非质子非质子介质中，过氧化钾（KO 2）对二氢萘进行氧化，生成单或二羟基萘醌，具体取决于羟基在萘部分上的相对位置。该反应主要在固-液界面进行，并且可以以良好的产率获得萘醌。
• Method of preventing polymer-scale formation
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0320227A2

  公开（公告）日：1989-06-14

  A method of preventing polymer scales from sticking in a polymerization vessel during the polymerization of a monomer having an ethylenically double bond, wherein said polymerization is carried out in a polymerization vessel of which the inner wall and other parts with which said monomer comes into contact during polymerization are previously first coated with (a) a coating solution comprising a cationic dye and the resulting coating is then coated with (b) a coating solution comprising at least one component selected from the group consisting of anionic polymeric compounds, amphoteric polymeric compounds and hydroxyl group-containing organic compounds. Polymer scale formation can be effectively prevented.

  一种在具有乙烯双键的单体聚合过程中防止聚合物鳞片粘附在聚合容器中的方法，其中所述聚合在聚合容器中进行，聚合容器的内壁和在聚合过程中与所述单体接触的其他部分之前先涂有(a)由阳离子染料组成的涂层溶液，然后在所得涂层上涂有(b)由至少一种从阴离子聚合物化合物、两性聚合物化合物和含羟基有机化合物组成的组中选出的组分组成的涂层溶液。可有效防止聚合物结垢。
• Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants
  申请人：Galenica Pharmaceuticals, Inc.

  公开号：EP1574217A1

  公开（公告）日：2005-09-14

  The present invention relates to polysaccharide conjugates that comprise: a polysaccharide having a minimum of seven saccharides attached to one or more molecules having an aldehyde or a ketone group through a direct covalent bond or covalently via a bifunctional linker in a manner that keeps the aldehyde or ketone group intact. The conjugates are useful as immuno-stimulants and adjuvants.

  本发明涉及多糖共轭物，它包括：至少有七个糖的多糖，通过直接共价键或通过双官能团连接剂共价连接到一个或多个具有醛基或酮基的分子上，其连接方式可保持醛基或酮基完好无损。这些共轭物可用作免疫刺激剂和佐剂。
• Use of imine-forming polysaccharides as adjuvants and immunostimulants
  申请人：Galenica Pharmaceuticals, Inc.

  公开号：US20020150585A1

  公开（公告）日：2002-10-17

  The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or via a bifunctional linker. The conjugates are useful as immuno-stimulants and adjuvants.

  本发明涉及多糖共轭物，它包括：与存在于抗原呈递细胞上的表面受体结合的多糖，与一种或多种直接或通过双功能连接体共价连接的具有稳定羰基的化合物结合。这些共轭物可用作免疫刺激剂和佐剂。
• Imine-forming polysaccharide adjuvants and immunostimulants
  申请人：Galenica Pharmaceuticals, Inc.

  公开号：US20040220142A1

  公开（公告）日：2004-11-04

  The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or via a bifunctional linker. The conjugates are useful as immuno-stimulants and adjuvants.

  本发明涉及多糖共轭物，它包括：与存在于抗原呈递细胞上的表面受体结合的多糖，与一种或多种直接或通过双功能连接体共价连接的具有稳定羰基的化合物结合。这些共轭物可用作免疫刺激剂和佐剂。