butan-2-one methylhydrazone | 7423-12-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: butan-2-one methylhydrazone
• 英文别名: 2-Butanone, methylhydrazone；N-(butan-2-ylideneamino)methanamine
• CAS: 7423-12-3
• 化学式: C₅H₁₂N₂
• 分子量: 100.164
• InChiKey: VBCGYWVDRKKFET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  butan-2-one methylhydrazone 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 以36%的产率得到1-Methyl-2-s-butylhydrazine
  参考文献：
  名称：

  环状肼中氮原子的空间位阻反转：N,N'-二烷基-1,3,4-恶二唑烷；1,3,4-噻二唑烷；和 4,5-苯并-1,2,3,6-四氢哒嗪

  摘要：

  N,N'-二异丙基取代的 1,3,4-恶二唑烷 3c、1,3,4-噻二唑烷 6、4,5-苯并-1,2,3,6-四氢哒嗪 8 和新的 3,4-二烷基-1，合成并研究了 3,4-恶二唑烷 9-14。N 原子的构型稳定性在从化合物 3c 到其 S-类似物 6 的过程中不会改变，并且在哒嗪 8 的情况下会降低。发现 3,4-二叔烷基-1,3,4-恶二唑烷 3d 和 11-14 是光学分辨率的有前途的目标。

  DOI：

  10.1007/bf02495930
• 作为产物：
  描述：

  甲基肼 、 丁酮 以 苯 为溶剂， 反应 3.0h， 生成 butan-2-one methylhydrazone
  参考文献：
  名称：

  Synthesis of 2-alkenylpyrazol-3(2H)-one derivatives under mild conditions

  摘要：

  The title compounds have been synthesized by a one-pot two-stage reaction of PCI,, ketone methyl-hydrazones and methyl acetoacetate. Both stages were carried out at room temperature and the corresponding 2-alkenyl-1,5-dimethylpyrazol-3(2H)-ones 5, which are an unknown series of pyrazolones, were obtained in good yields. Use of a variety of enolizable ketones has shown that the reaction always occurs with the predominance of the (E)-isomer. X-Ray structure determinations of an (E)- and a (Z)-derivative [(E)-5c.HCl and (Z)-5b] permitted the assignment of their structures. The aromaticity of these derivatives is discussed.

  DOI：

  10.1039/p19920001729

文献信息

• Substitution at 4-position in 1,2,3σ²-diazaphosphole by phosphorus trichloride
  作者：Jörg Luber、Alfred Schmidpeter

  DOI：10.1039/c39760000887

  日期：——

  2-Methyl-1,2,3σ2-diazaphospholes are obtained as hydrochlorides from methylhydrazones and an ecxess of PCl3 which, with longer reaction times, give the 4-dichlorophosphino-derivatives; 4-alkyl substituted diazaphospholes may be separated from their mixture with 4-unsubstituted compounds by the use of this reaction.

  2-甲基-1,2,3Ï2-二氮杂萘酚以盐酸盐形式从甲基肼和少量 PCl3 中获得，反应时间越长，得到的 4-二氯膦衍生物就越多；利用这种反应，可以将 4-烷基取代的二氮杂萘酚从它们与 4-未取代化合物的混合物中分离出来。
• Azoxy compound having use in a process for preparing foamed structures
  申请人：Pennwalt Corporation

  公开号：US04228069A1

  公开（公告）日：1980-10-14

  An acid sensitive, mono- or di- azoxy compound is reacted with an acidulous acidic polymerizable medium to form a cellular polymeric structure. An unsymmetrical azoxy compound is also provided having the formula ##STR1## where n is 1 or 2 and R.sup.8 is movalent when n is 1 and divalent when n is 2.

  一种酸敏感的单或双偶氮化合物与酸性聚合介质反应，形成细胞聚合物结构。还提供了一种非对称的偶氮化合物，其化学式为##STR1##其中n为1或2，当n为1时，R.sup.8为单价，当n为2时，R.sup.8为二价。
• N-Alkylhydrazones of aliphatic ketones in the synthesis of 1,3,4-trisubstituted non-symmetric pyrazoles
  作者：Sergey P. Ivonin、Bohdan B. Kurpil’、Eduard B. Rusanov、Oleksandr O. Grygorenko、Dmitry M. Volochnyuk

  DOI：10.1016/j.tetlet.2014.02.058

  日期：2014.4

  Reactions of N-alkylhydrazones of aliphatic ketones with the Vilsmeier-Haack reagent (DMF-POCl3) were evaluated as a promising approach toward the synthesis of trisubstituted non-symmetric pyrazoles. It was found that either 1,3,4-trialkylpyrazoles or 1,3-dialkylpyrazole-4-carbaldehydes could be obtained in these transformations in high yields (72-83%), in a regioselective manner. (C) 2014 Elsevier Ltd. All rights reserved.
• Baccolini, Graziano, Journal of the Chemical Society. Perkin transactions I, 1989, p. 1053 - 1056
  作者：Baccolini, Graziano

  DOI：——

  日期：——
• The crystal structure of dicyclopentadienylvanadium monochloride and its implications for the structures of other d2 dicyclopentadienyl compounds
  作者：Benjamin F. Fieselmann、Galen D. Stucky

  DOI：10.1016/s0022-328x(00)80841-4

  日期：1977.9