(2-Amino-1-phenylethyl)-diphenylphosphin | 49749-93-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-Amino-1-phenylethyl)-diphenylphosphin
• 英文别名: 2-Diphenylphosphanyl-2-phenylethanamine
• CAS: 49749-93-1
• 化学式: C₂₀H₂₀NP
• 分子量: 305.359
• InChiKey: ZWXNOAIZYGVFBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2-Amino-1-phenylethyl)-diphenylphosphin 在 NaOH 、 Bu₄NBr 作用下， 以 四氢呋喃 、 sodium hydroxide 、 苯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of the first chiral phosphorous chelate aminophosphino–carbene complex and its applications in stereoselective addition reactions

  摘要：

  The first phosphorous chelate chiral aminophosphinomethyl carbene complex 5 has been synthesized. Its conjugated base represents a new chiral cr-unsubstituted amide enolate equivalent for stereoselective addition reactions. The structure of the major diastereoisomer of the aldol addition complex between 5 and pO(2)N-C6H4-CHO, solved by X-ray diffraction, shows that the (S)-enantiomer of the conjugated base of 5 reacts preferentially with the re face of the carbonyl function. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0020-1693(99)00372-2

文献信息

• Synthesis of the first chiral phosphorous chelate aminophosphino–carbene complex and its applications in stereoselective addition reactions
  作者：Stefano Maiorana、Antonio Papagni、Emanuela Licandro、Dario Perdicchia、Clara Baldoli、Claudia Graiff、Antonio Tiripicchio

  DOI：10.1016/s0020-1693(99)00372-2

  日期：1999.12

  The first phosphorous chelate chiral aminophosphinomethyl carbene complex 5 has been synthesized. Its conjugated base represents a new chiral cr-unsubstituted amide enolate equivalent for stereoselective addition reactions. The structure of the major diastereoisomer of the aldol addition complex between 5 and pO(2)N-C6H4-CHO, solved by X-ray diffraction, shows that the (S)-enantiomer of the conjugated base of 5 reacts preferentially with the re face of the carbonyl function. (C) 1999 Elsevier Science S.A. All rights reserved.