2-ethyl-3a,4,7,7a-tetrahydro-4,7-epioxido-isoindole-1,3-dione | 32620-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-ethyl-3a,4,7,7a-tetrahydro-4,7-epioxido-isoindole-1,3-dione
• 英文别名: N-Ethyl-3,6-epoxy-4-cyclohexene-1,2-dicarbimide；2-ethyl-3a,4,7,7a-tetrahydro-4,7-epoxyisoindole-1,3-dione
• CAS: 32620-87-4
• 化学式: C₁₀H₁₁NO₃
• mdl: MFCD01000299
• 分子量: 193.202
• InChiKey: SVXGVAQSQSAJHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESS FOR THE COVALENT COUPLING OF TWO MOLECULES BY MEANS OF A DIELS-ALDER REACTION WITH INVERSE ELECTRON REQUIREMENT
  申请人：Wiessler Manfred

  公开号：US20100016545A1

  公开（公告）日：2010-01-21

  The present invention relates to a process for linking two molecules by means of a Diels Alder reaction with inverse electron requirement (DARinv), comprising the following steps: reaction of a (a) triazine or tetrazine with one or more electron-attracting substituents on the ring as a diene component, the electron-attracting substituents being selected from: COOR C(O)NR 2 CX 3 (X=halogen) halogen CN SO 2 —R or SO 3 —R PR 2 wherein R═H, alkyl, aryl, heterocycle, which in turn may be substituted, where appropriate, with alkyl, OH, SH, halogen, aryl, heterocycle, nitro, carboxyamido or amine group. —heterocyclic rings having 1, 2 or 3 N, O or S atoms with a ring size of 5 or 6 ring members, which are substituted with at least one carboxyl, sulfonic acid or phosphone group with (b) an isolated double bond or triple bond in a (hetero)carbocyclic ring or an isolated olefinic double bond or triple bond in a linear or branched hydrocarbon chain which may also contain heteroatoms, where appropriate, as a dienophile component.

  本发明涉及一种利用逆电子需求的Diels-Alder反应（DARinv）将两种分子通过连接的方法，包括以下步骤：将（a）三嗪或四嗪与环上的一个或多个吸电子取代基反应作为二烯组分，所述吸电子取代基被选择自：COOR、C（O）NR2、CX3（X=卤）、卤、CNSO2—R或SO3—RPR2，其中R=H、烷基、芳基、杂环，后者可能被适当地取代，如有必要，可用烷基、OH、SH、卤、芳基、杂环、硝基、羧基氨基或胺基团取代；（b）一种孤立的双键或三键存在于（杂）碳环上，或者一种孤立的烯烃双键或三键存在于线性或支链烃链中，该链也可能含有杂原子，如有必要，作为二烯酰组分。
• Shape-memory-self-healing polymers (SMSHPS)
  申请人：University of Florida Research Foundation, Inc.

  公开号：US10202484B2

  公开（公告）日：2019-02-12

  A shape-memory self-healing polymeric network (SMSHP) is useful as a molded part, a coating, or as a matrix for a composite that can be repaired by heating to a controlled temperature. The SMSHP has thermally reversible repeating units where a thermally reversible adduct is situated between two common linking units formed during a polymerization process between thermally reversible monomers and cross-linking monomers. Optionally, other repeating units can be present from other monomers. Shape-memory results when the SMSHP is warmed to a temperature in excess of its glass transition temperature and self-healing then proceeds when a higher temperature is achieved where thermally reversible adducts dissociates to complementary groups that subsequently reform the adduct without distortion of the memorized shape. The thermally reversible adducts can be Diels-Alder (DA) adducts in a polyurethane, poly urea, or amine epoxy SMSHP network.

  形状记忆自修复聚合物网络（SMSHP）可用作模制件、涂层或复合材料的基体，通过加热至可控温度进行修复。SMSHP 具有热可逆重复单元，其中热可逆加合物位于热可逆单体和交联单体聚合过程中形成的两个共同连接单元之间。此外，其他单体也可能含有其他重复单元。当 SMSHP 升温至超过其玻璃化转变温度时，会产生形状记忆；当温度升高时，热可逆加成物会解离成互补基团，随后对加成物进行重整，而不会扭曲已记忆的形状。热可逆加合物可以是聚氨酯、聚脲或胺环氧 SMSHP 网络中的 Diels-Alder (DA) 加合物。
• MU opioid receptor modulators
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10702498B2

  公开（公告）日：2020-07-07

  Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.

  本文特别描述了调节μ阿片受体活性的组合物和方法。
• OPTICAL FILM AND DISPLAY DEVICE INCLUDING SAME
  申请人：Samsung Electronics Co., Ltd.

  公开号：US20130172503A1

  公开（公告）日：2013-07-04

  An optical film including a polymer including a repeating unit A including a repeating unit represented by the following Chemical Formulas 1 to 3, or a combination thereof; and a repeating unit B derived from a monomer having an unsaturated bond copolymerizable with the repeating unit A, wherein the optical film has a short wavelength dispersion of an in-plane phase-difference value (R e ) (450 nm/550 nm) ranging from about 0.81 to about 1.20, and a long wavelength dispersion of an in-plane phase-difference value (R e ) (650 nm/550 nm) ranging from about 0.90 to about 1.18: wherein, in Chemical Formulas 1 to 3, the variables R 1 to R 21 are defined herein.
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.