(1Z)-1-[[(Phenylsulfonyl)oxy]imino]naphthalen-2(1H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (1Z)-1-[[(Phenylsulfonyl)oxy]imino]naphthalen-2(1H)-one
• 英文别名: [(Z)-(2-oxonaphthalen-1-ylidene)amino] benzenesulfonate
• 化学式: C₁₆H₁₁NO₄S
• 分子量: 313.334
• InChiKey: RRNZUVOWYYOMQM-MSUUIHNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  乙醇 、 (1Z)-1-[[(Phenylsulfonyl)oxy]imino]naphthalen-2(1H)-one 以 乙醇 为溶剂， 生成 ethyl (E)-3-(2-cyanophenyl)acrylate
  参考文献：
  名称：

  Isoindolinone enantiomers having affinity for the dopamine D4 receptor

  摘要：

  PD 108635 (1) was identified as a potent dopamine D-4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D-4 affinity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00252-2
• 作为产物：
  描述：

  苯磺酰氯 、 1-亚硝基-2-萘酚 在 吡啶 作用下， 生成 (1Z)-1-[[(Phenylsulfonyl)oxy]imino]naphthalen-2(1H)-one
  参考文献：
  名称：

  Isoindolinone enantiomers having affinity for the dopamine D4 receptor

  摘要：

  PD 108635 (1) was identified as a potent dopamine D-4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D-4 affinity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00252-2

文献信息

• Isoindolinone enantiomers having affinity for the dopamine D4 receptor
  作者：Thomas R. Belliotti、Wouter A. Brink、Suzanne R. Kesten、John R. Rubin、David J. Wustrow、Kim T. Zoski、Steven Z. Whetzel、Ann E. Corbin、Thomas A. Pugsley、Thomas G. Heffner、Lawrence D. Wise

  DOI：10.1016/s0960-894x(98)00252-2

  日期：1998.6

  PD 108635 (1) was identified as a potent dopamine D-4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D-4 affinity. (C) 1998 Elsevier Science Ltd. All rights reserved.