2-hydroxyethylpentadecylamine | 98389-74-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-hydroxyethylpentadecylamine
• 英文别名: 2-(Pentadecylamino)ethanol
• CAS: 98389-74-3
• 化学式: C₁₇H₃₇NO
• 分子量: 271.487
• InChiKey: QJXHPFHKGPEMAM-UHFFFAOYSA-N

物化性质

• 沸点：
  386.8±15.0 °C(Predicted)
• 密度：
  0.860±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  19
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxyethylpentadecylamine 、 2-氯乙氧基乙醇 生成 2-[2-(2-hydroxyethoxy)ethyl-pentadecylamino]ethanol
  参考文献：
  名称：

  WEDLER C.; HAAGE K.; HERBST M.; TISCHER H.; KNOPE E., ABH. AKAD. WISS. DDR. ABT. MATH., NATURWISS., TECHN.,(1986) N 1N, 589-594

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氯十五烷 、 C.I.酸性橙108 以 乙醇 为溶剂， 反应 24.0h， 生成 2-hydroxyethylpentadecylamine
  参考文献：
  名称：

  Diamine derivative anti-Trichomonas vaginalis and anti-Tritrichomonas foetus activities by effect on polyamine metabolism

  摘要：

  Human and bovine trichomoniasis are sexually transmitted diseases (STD) caused by Trichomonas vaginalis and Tritrichomonas foetus, respectively. Human trichomoniasis is the most common non-viral STD in the world and bovine trichomoniasis causes significant economic losses to breeders. Considering the significant impact of the infections caused by these protozoa and the treatment failures, the search for new therapeutic alternatives becomes crucial. In this study the effect of diamines and amino alcohols in the in vitro viability of trichomonads was evaluated. Screening demonstrated the high activity of diamine 4 against these protozoa. Although cytotoxicity against HMVII cell line and slight hemolysis were observed in vitro, the compound showed no toxic effect on the Galleria mellonella in vivo model. Importantly, diamine 4 was active against both trichomonads species at 6 h and 24 h of incubation, and these effects was reverted by putrescine, a polyamine, suggesting competition for the same metabolic pathway. These findings indicate that the mechanism of action of diamine 4 is through the polyamine metabolism, a pathway distinct from that presented by metronidazole, the drug usually used to treat trichomoniasis and to which resistance is widely reported. These data demonstrate the importance of diamines as potential novel candidates as anti-T. vaginalis and anti-T. foetus agents.

  DOI：

  10.1016/j.biopha.2017.09.007

文献信息

• Substituierte Aminoalkanolphospholipide und Verfahren zu ihrer Herstellung
  申请人：A. Nattermann & Cie. GmbH

  公开号：EP0107120A1

  公开（公告）日：1984-05-02

  Die Erfindung betrifft neue substituierte Aminoalkanolphospholipide der allgemeinen Formel 1 und Verfahren zu ihrer Herstellung. Die Verbindungen zeigen starke biologische Aktivität und können z.B. in Arzneimitteln und im Pflanzenschutz eingesetzt werden. Sie besitzen z.B. blutdrucksenkende, entzündungshemmende. tumorhemmende und antiatherosklerotische Eigenschaften.

  本发明涉及通式 1 的新型取代氨基烷醇磷脂及其制备工艺。 及其制备工艺。这些化合物具有很强的生物活性，可用于制药和植物保护等领域。例如，它们具有抗高血压、抗炎、抗肿瘤和抗动脉粥样硬化的特性。
• Crystalline polyolefin composition
  申请人：Chisso Corporation

  公开号：EP0416321A1

  公开（公告）日：1991-03-13

  A crystalline polyolefin composition which provides molded articles having improved stiffness characteristics is disclosed, comprising 100 parts by weight of a crystalline polyolefin, (A) from 0.001 to 1 part by weight of a fluorophosphite compound represented by formula (I): wherein R represents an alkylidene group having from 1 to 4 carbon atoms or a sulfur atom; Ar1 and Ar2, which may be the same or different, each represents an alkylarylene group or a cycloalkylarylene group; and n represents 0 or 1, and (B) from 0.001 to 1 part by weight of at least one compound selected from the group consisting of (1) an aliphatic monocarboxylic acid salt with lithium or sodium, (2) a dithiocarbamic acid salt with lithium, sodium or potassium, (3) a 2-mercaptobenzothiazole salt with lithium, sodium or potassium, (4) a 2-mercaptobenzimidazole salt with lithium, sodium or potassium and (5) a benzotriazole salt with lithium, sodium or potassium. A crystalline polyolefin composition which provides molded articles having improved stiffness charateristics is also disclosed, comprising 100 parts by weight of a crystalline polyolefin, (A) from 0.001 to 1 part by weight of a fluorophosphite compound represented by formula (I) shown above, (B ) from 0.001 to 1 part by weight of at least one compound selected from the group consisting of (1) an aliphatic monocarboxylic acid salt with potassium, strontium or barium, (2) a hydroxy-higher fatty acid salt with potassium, strontium or barium, (3) an aliphatic polycarboxylic acid salt with lithium, sodium, potassium, strontium or barium, (4) a salt of an aliphatic hydroxy acid having form 2 to 6 carbon atoms with lithium, sodium, potassium, magnesium, strontium or barium, (5) an aromatic carboxylic acid salt with lithium, sodium, strontium, barium or aluminum, (6) a glutamic acid salt with lithium, sodium, potassium, strontium or barium, (7) an aliphatic phosphoric acid salt with sodium, potassium, calcium, strontium or barium, (8) a lithium, sodium, potassium or barium salt of a cyclic phosphorus compound represented by formula (II): wherein Ar3 and Ar4, which may be the same or different, each represents an arylene group, an alkylarylene group, a cycloalkylarylene group, an arylarylene group or an aralkylarylene group; M represents lithium, sodium, potassium or barium; and m represents an atomic valence of M, (9) magnesium or aluminum hydroxide, (10) magnesium oxide, (11) magnesium or calcium carbonate and (12) hydrotalcite, and (C) from 0.01 to 1 part by weight of an aliphatic amine.

  本发明公开了一种结晶聚烯烃组合物，该组合物可提供具有改进的刚度特性的模塑制品，该组合物包括按重量计100份的结晶聚烯烃、(A)按重量计0.001至1份的由式(I)代表的亚磷酸氟化合物： 其中 R 代表具有 1 至 4 个碳原子的亚烷基或硫原子；Ar1 和 Ar2 可以相同或不同，各自代表烷基芳基或环烷基芳基；n 代表 0 或 1，以及 (B) 0.(1) 锂或钠的脂肪族一羧酸盐，(2) 锂、钠或钾的二硫代氨基甲酸盐、(3) 锂、钠或钾的 2-巯基苯并噻唑盐， (4) 锂、钠或钾的 2-巯基苯并咪唑盐， (5) 锂、钠或钾的苯并三唑盐。 本发明还公开了一种结晶聚烯烃组合物，该组合物可提供具有改进的刚度特性的模塑制品，其成分包括 100 份（重量）结晶聚烯烃、(A) 0.001 至 1 份（重量）由上文式(I)代表的亚磷酸氟化合物、(B ) 0.(1)钾、锶或钡的脂肪族一羧酸盐；(2)钾、锶或钡的羟基高级脂肪酸盐；(3)锂、钠、钾、锶或钡的脂肪族多羧酸盐；(4)锂、钠、钾、镁、锶或钡的具有 2 至 6 个碳原子的脂肪族羟基酸盐、(5) 锂、钠、锶、钡或铝的芳香族羧酸盐； (6) 锂、钠、钾、锶或钡的谷氨酸盐、(7) 含有钠、钾、钙、锶或钡的脂肪族磷酸盐， (8) 由式（II）代表的环磷化合物的锂、钠、钾或钡盐： 其中 Ar3 和 Ar4 可以相同或不同，各自代表芳基、烷芳基、环烷芳基、芳基芳基或芳基芳基；M 代表锂、钠、钾或钡；m 代表 M 的原子价，(9) 氢氧化镁或铝，(10) 氧化镁，(11) 碳酸镁或碳酸钙和 (12) 水滑石，以及 (C) 0.01至1份重量的脂肪族胺。
• Phosphorous amine lubricant additives
  申请人：THE ELCO CORPORATION

  公开号：EP0456888A1

  公开（公告）日：1991-11-21

  Lubricant additives are produced by reacting an alkoxylated amine with phosphorous acid. The additives preferably also contain a boron moiety which is reacted with the phosphorous acid and amine, preferably in a one step reaction. More preferably, a mono-functional alcohol or a long-chain aliphatic carboxylic acid is added to this mixture. The additives are particularly useful in metalworking oils and particularly as extreme pressure additives to replace the currently used chlorinated paraffin additives.

  润滑油添加剂是通过烷氧基化胺与磷酸反应制得的。添加剂最好还含有一个硼基，该硼基与磷酸和胺反应，最好是一步反应。更优选的是，在该混合物中加入单官能醇或长链脂肪族羧酸。这种添加剂在金属加工油中特别有用，尤其是作为极压添加剂，可以取代目前使用的氯化石蜡添加剂。
• Lubricating compositions, greases, and aqueous fluids containing the combination of a dithiocarbamate compound and an organic polysulfide
  申请人：THE LUBRIZOL CORPORATION

  公开号：EP0638631A1

  公开（公告）日：1995-02-15

  This invention relates to a lubricating composition comprising an oil of lubricating viscosity, (A) at least one dithiocarbamate compound, and (B) at least one organic polysulfide. The invention also relates to greases and aqueous compositions which contain this combination. The compositions have good antiwear or extreme pressure properties. The combination also provides improved oxidation resistance and thermal stability to fluids.

  本发明涉及一种润滑组合物，其成分包括具有润滑粘度的油、(A) 至少一种二硫代氨基甲酸盐化合物和 (B) 至少一种有机多硫化物。本发明还涉及含有这种组合物的润滑脂和水性组合物。这些组合物具有良好的抗磨损或极压性能。该组合物还能提高流体的抗氧化性和热稳定性。
• Lubricating compositions
  申请人：THE LUBRIZOL CORPORATION

  公开号：EP0646639A1

  公开（公告）日：1995-04-05

  This invention relates to a lubricating composition comprising a major amount of an oil of lubricating viscosity, (A) an hydrocarbyl phosphite, wherein each hydrocarbyl group is saturated and independently contains from about 12 to about 24 carbon atoms, (B) an organic polysulfide, and (C) (i) a borated overbased metal salt of an acidic organic compound, (ii) a combination of a borated dispersant and a phosphorus antiwear or extreme pressure agent selected from the group consisting of a phosphoric acid ester or salt thereof, a lower alkyl phosphite, and a phosphorus-containing carboxylic acid, ester, ether, or amide, or (iii) a mixture of (i) and (ii). These compositions provide improved frictional properties to lubricating composition while maintaining the extreme pressure protection of the lubricant. The lubricating compositions have good thermal stability.

  本发明涉及一种润滑组合物，该组合物包含主要量的具有润滑粘度的油、(A) 一种烃基亚磷酸酯，其中每个烃基都是饱和的且独立含有约 12 至约 24 个碳原子；(B) 一种有机多硫化物；以及 (C) (i) 一种酸性有机化合物的硼化过基金属盐、(ii) 硼酸盐分散剂和磷抗磨剂或极压剂的组合，磷抗磨剂或极压剂选自磷酸酯或其 盐、低级烷基亚磷酸酯和含磷羧酸、酯、醚或酰胺组成的组，或 (iii) (i) 和 (ii) 的混合物。这些组合物可改善润滑组合物的摩擦性能，同时保持润滑剂的极压保护性能。这些润滑组合物具有良好的热稳定性。