1-adamantan-1-yl-3-(tetrahydro-2H-pyran-4-yl)urea | 1132783-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 1-adamantan-1-yl-3-(tetrahydro-2H-pyran-4-yl)urea
• 英文别名: 1-(1-Adamantyl)-3-(oxan-4-yl)urea
• CAS: 1132783-18-6
• 化学式: C₁₆H₂₆N₂O₂
• 分子量: 278.395
• InChiKey: NAKAJAQCPDVHKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氨基四氢吡喃 、 异氰酸1-金刚烷酯 以 氯仿 为溶剂， 反应 2.0h， 以25%的产率得到1-adamantan-1-yl-3-(tetrahydro-2H-pyran-4-yl)urea
  参考文献：
  名称：

  SOLUBLE EPOXIDE HYDROLASE INHIBITORS

  摘要：

  本文披露了抑制可溶性环氧水解酶（sEH）的酰胺、硫酰胺、脲和硫脲化合物和配方，以及制备这些化合物和配方的方法，以及使用这些化合物和配方治疗患有这些化合物和配方的患者的方法。这些化合物、配方和方法对治疗多种由sEH介导的疾病，包括高血压、心血管、炎症和糖尿病相关疾病，具有益处。

  公开号：

  US20090082423A1

文献信息

• FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF
  申请人：SHANGHAI DE NOVO PHARMATECH CO., LTD.

  公开号：US20180022752A1

  公开（公告）日：2018-01-25

  This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.
• [EN] SOLUBLE EPOXIDE HYDROLASE INHIBITORS<br/>[FR] INHIBITEURS DE L'ÉPOXYDE HYDROLASE SOLUBLE
  申请人：ARETE THERAPEUTICS INC

  公开号：WO2009035927A2

  公开（公告）日：2009-03-19

  Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic -related diseases.
• SOLUBLE EPOXIDE HYDROLASE INHIBITORS
  申请人：Anandan Sampath-Kumar

  公开号：US20090082423A1

  公开（公告）日：2009-03-26

  Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic-related diseases.

  本文披露了抑制可溶性环氧水解酶（sEH）的酰胺、硫酰胺、脲和硫脲化合物和配方，以及制备这些化合物和配方的方法，以及使用这些化合物和配方治疗患有这些化合物和配方的患者的方法。这些化合物、配方和方法对治疗多种由sEH介导的疾病，包括高血压、心血管、炎症和糖尿病相关疾病，具有益处。