5-(dimethylamino)-N-undec-10-ynylnaphthalene-1-sulfonamide | 188584-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(dimethylamino)-N-undec-10-ynylnaphthalene-1-sulfonamide
• CAS: 188584-22-7
• 化学式: C₂₃H₃₂N₂O₂S
• 分子量: 400.585
• InChiKey: LHXFLCNBWOENMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.94
• 重原子数：
  28.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  49.41
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-benzoyl-4-iodo-L-phenylalanine methylester 、 5-(dimethylamino)-N-undec-10-ynylnaphthalene-1-sulfonamide 在 copper(l) iodide 、 四(三苯基膦)钯 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以82%的产率得到(S)-2-Benzoylamino-3-{4-[11-(5-dimethylamino-naphthalene-1-sulfonylamino)-undec-1-ynyl]-phenyl}-propionic acid methyl ester
  参考文献：
  名称：

  Palladium-catalysed attachment of labels with acetylenic linker arms to biological molecules

  摘要：

  Palladium-catalysed coupling has been used to attach a series of fluorescent (acridonyl, pyrenyl, fluoresceinyl, dansyl and ruthenium phenanthrolinyl) and enzymic (biotinyl) labels containing a terminal alkyne to electophilic biological molecules based on amino acids, nucleosides and steroids. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(96)01085-x
• 作为产物：
  描述：

  10-十一碳炔酸 在 lithium aluminium tetrahydride 、 氯化亚砜 、 氨 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 32.0h， 生成 5-(dimethylamino)-N-undec-10-ynylnaphthalene-1-sulfonamide
  参考文献：
  名称：

  Preparation of biological labels with acetylenic linker arms

  摘要：

  The preparation of a series of fluorescent labels based on acridone, pyrene, fluorescein, dimedlylaminonaphthalenesulphonamide and tris-l,10-phenanthroline ruthenium and an enzymic label based on biotin with spacers containing a terminal acetylene is described. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(96)01084-8

文献信息

• Preparation of biological labels with acetylenic linker arms
  作者：Geoffrey T. Crisp、Jeffrey Gore

  DOI：10.1016/s0040-4020(96)01084-8

  日期：1997.1

  The preparation of a series of fluorescent labels based on acridone, pyrene, fluorescein, dimedlylaminonaphthalenesulphonamide and tris-l,10-phenanthroline ruthenium and an enzymic label based on biotin with spacers containing a terminal acetylene is described. (C) 1997, Elsevier Science Ltd.
• Palladium-catalysed attachment of labels with acetylenic linker arms to biological molecules
  作者：Geoffrey T. Crisp、Jeffrey Gore

  DOI：10.1016/s0040-4020(96)01085-x

  日期：1997.1

  Palladium-catalysed coupling has been used to attach a series of fluorescent (acridonyl, pyrenyl, fluoresceinyl, dansyl and ruthenium phenanthrolinyl) and enzymic (biotinyl) labels containing a terminal alkyne to electophilic biological molecules based on amino acids, nucleosides and steroids. (C) 1997, Elsevier Science Ltd.