4-[1-[(2,5-Dichlorophenyl)methyl]-2-(methoxymethyl)imidazo[4,5-c]pyridin-6-yl]morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 4-[1-[(2,5-Dichlorophenyl)methyl]-2-(methoxymethyl)imidazo[4,5-c]pyridin-6-yl]morpholine
• 英文别名: 4-[1-[(2,5-dichlorophenyl)methyl]-2-(methoxymethyl)imidazo[4,5-c]pyridin-6-yl]morpholine
• 化学式: C₁₉H₂₀Cl₂N₄O₂
• 分子量: 407.3
• InChiKey: KHTQLBAKPGTZIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  52.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
  申请人：UCB Biopharma SRL

  公开号：EP3080112B1

  公开（公告）日：2020-06-03
• Imidazopyridine Derivatives as Modulators of TNF Activity
  申请人：UCB BIOPHARMA SPRL

  公开号：US20170158688A1

  公开（公告）日：2017-06-08

  A series of substituted 1H imidazo[4,5-c]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
• US9920052B2
  申请人：——

  公开号：US9920052B2

  公开（公告）日：2018-03-20