2-Chlor-10-<3'-(4''-methyl-1''-piperazinyl)-propyl>-phenothiazin | 3684-78-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2-Chlor-10-<3'-(4''-methyl-1''-piperazinyl)-propyl>-phenothiazin
• 英文别名: Prochloroperazine；3-chloro-10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine；prochlorperazine；3-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
• CAS: 3684-78-4
• 化学式: C₂₀H₂₄ClN₃S
• 分子量: 373.95
• InChiKey: QIIWGPSXDUSNTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• TREATMENT OF PROTEIN AGGREGATION DISEASES
  申请人：Wilson Stuart Mark

  公开号：US20100035859A1

  公开（公告）日：2010-02-11

  A method of treatment for the prevention or therapy of a protein aggregation disease includes the administration in combination of a first active medicament and a second active medicament, wherein the first active medicament is active to impede aggregation of amyloid protein and the second active medicament is active to disaggregate previously formed aggregates of amyloid protein.
• PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE
  申请人：McKearn John

  公开号：US20140051765A1

  公开（公告）日：2014-02-20

  Disclosed herein are new oral pharmaceutical compositions of MGBG and related polyamine analogs, polyamine biosynthesis inhibitors, polyamine inhibitors of AMD-I and regulators of osteopontin, and their application for the treatment of disease.
• US8383617B2
  申请人：——

  公开号：US8383617B2

  公开（公告）日：2013-02-26
• US9616035B2
  申请人：——

  公开号：US9616035B2

  公开（公告）日：2017-04-11
• [EN] TREATMENT OF PROTEIN AGGREGATION DISEASES<br/>[FR] TRAITEMENT DE MALADIES D'AGRÉGATION DE PROTÉINES
  申请人：PAD PHARMA LTD

  公开号：WO2008092898A1

  公开（公告）日：2008-08-07

  [EN] Prevention or treatment of protein aggregation diseases such as Alzheimer's disease is conducted using a combination of a phenothiazine such as fluphenazine to impede aggregation of amyloid protein and a tricyclic antidepressant such as trimipramine to disaggregate already formed protein aggregations.
  [FR] La présente invention concerne la prévention ou le traitement de maladies d'agrégation de protéines telles que la maladie d'Alzheimer consistant à utiliser une combinaison d'une phénothiazine telle que la fluphénazine pour bloquer l'agrégation des la protéine amyloïde et un antidépresseur tricyclique tel que la trimipramine pour désagréger des agrégations déjà formées.