bis(2-(N-Bu)aminoethyl)sulfide | 743380-32-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(2-(N-Bu)aminoethyl)sulfide
• 英文别名: N-[2-[2-(tert-butylamino)ethylsulfanyl]ethyl]-2-methylpropan-2-amine
• CAS: 743380-32-7
• 化学式: C₁₂H₂₈N₂S
• 分子量: 232.434
• InChiKey: PYCOQQFUNQCECL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis(2-(N-Bu)aminoethyl)sulfide 、 tin(II) dimethylamide 以 苯 为溶剂， 以52%的产率得到5-thia-2,8-di-N-butyl-2,8-diaza-1-stanna(II)-bicyclo[3.3.0(1,5)]octane
  参考文献：
  名称：

  Tzschach, A.; Scheer, M.; Jurkschat, K., Zeitschrift fur Anorganische und Allgemeine Chemie

  摘要：

  DOI：
• 作为产物：
  描述：

  硫化碱 、 tert-butyl-(2-chloro-ethyl)-amine 以62%的产率得到
  参考文献：
  名称：

  TZSCHACH, A.;SCHEER, M.;JURKSCHAT, K., Z. ANORG. UND ALLG. CHEM., 1984, 515, N 8, 147-150

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION
  申请人：Cellix Bio Private Limited

  公开号：US20220048850A1

  公开（公告）日：2022-02-17

  The disclosures herein provide compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These compounds may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, intravenous, spray, parenteral, lozenge, solution, syrup, sachet, transdermal administration, or injection. Such compositions may be used to treatment of inflammation or its associated complications.

  本文披露了I式化合物及其药物可接受的盐，以及其多晶形、对映异构体、立体异构体、溶剂化物和水合物。这些化合物可以制成药物组合物。药物组合物可以制成口服、静脉注射、喷雾、注射、含片、溶液、糖浆、小包装、经皮给药等药物形式。这些组合物可以用于治疗炎症或其相关并发症。
• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。
• Olefin polymerization catalysts and olefin polymer production methods using said olefin polymerization catalysts
  申请人：JSR Corporation

  公开号：EP1046654A1

  公开（公告）日：2000-10-25

  An object of this invention is to provide a polymerization catalyst that can be used for the polymerization of olefins. Another object of this invention is to present a method of producing excellent olefin polymers with high copolymerization properties and high molecular weight using the polymerization catalyst. The catalyst of this invention is an olefin polymerization catalyst which contains a reaction product obtained from vanadium oxytrichloride and 2,2'-thiobis(6-5-butyl-4-methylphenyl), an organic aluminum compound, such as trimethylaluminum, and an ionized ionic compound, such as N,N-dimethylanilinium tetrakis(pentafluorophenyl)borate, and the like. By using this catalyst to polymerize ethylene with an α-olefin, such as propylene, 1-heptene, 1-octene, and the like., or a non-conjugated diene, such as 5-ethylidene-2-norbornene, and the like., a polymer of high copolymerization properties can be obtained.

  本发明的一个目的是提供一种可用于烯烃聚合的聚合催化剂。本发明的另一个目的是提出一种使用该聚合催化剂生产具有高共聚合性能和高分子量的优良烯烃聚合物的方法。本发明的催化剂是一种烯烃聚合催化剂，它含有由三氯氧钒和 2,2'-硫代双（6-5-丁基-4-甲基苯基）、有机铝化合物（如三甲基铝）和离子化离子化合物（如 N,N-二甲基苯胺四（五氟苯基）硼酸酯）等得到的反应产物。使用这种催化剂使乙烯与α-烯烃（如丙烯、1-庚烯、1-辛烯等）或非共轭二烯（如 5-亚乙基-2-降冰片烯等）聚合，可获得共聚性能高的聚合物。
• Compositions and methods for the treatment of neurological disorders
  申请人：Kandula Mahesh

  公开号：US10208014B2

  公开（公告）日：2019-02-19

  The invention relates to valproic acid derivatives or pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of valproic acid derivatives, and methods for treating or preventing neurological disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, bipolar disorder, migraine, schizophrenia, depression, Alzheimer's disease, cancer, HIV and familial adenomatous polyposis.

  本发明涉及丙戊酸衍生物或药物可接受盐，以及它们的多晶型物、溶剂、对映体、立体异构体和水合物。包含有效量丙戊酸衍生物的药物组合物以及治疗或预防神经系统疾病的方法可配制成口服、口腔、直肠、局部、透皮、透粘膜、静脉注射、肠外给药、糖浆或注射剂。此类组合物可用于治疗癫痫、躁郁症、偏头痛、精神分裂症、抑郁症、阿尔茨海默病、癌症、艾滋病和家族性腺瘤性息肉病。
• Compositions and methods for the treatment of cancer
  申请人：CELLIX BIO PRIVATE LIMITED

  公开号：US10858349B2

  公开（公告）日：2020-12-08

  The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII and, the methods for the treatment of cancer and infectious diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cancer, neoplasm, infections and skin diseases.

  本发明涉及这些化合物或其药用可接受的多晶型物、溶剂、对映体、立体异构体和水合物。包含有效量的式 I、式 II、式 III、式 IV、式 V、式 VI、式 VII 和式 VIII 化合物的药物组合物以及治疗癌症和传染性疾病的方法可配制成口服、口腔、直肠、局部、透皮、透粘膜、锭剂、喷雾剂、静脉注射、口服溶液、颊粘膜层片剂、肠外给药、糖浆或注射剂。这些成分可用于治疗癌症、肿瘤、感染和皮肤病。