8-(2-Chloro-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-(2-Chloro-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
• 英文别名: 8-(2-chloroethyl)-1,3-dimethyl-7H-purine-2,6-dione
• 化学式: C₉H₁₁ClN₄O₂
• 分子量: 242.66
• InChiKey: MWPXFDPJSZRYPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• USE OF DPAS AND CO-POLYMERS FOR HYPERLIPIDEMIA AND ATHEROSCLEROSIS ALONG WITH REDUCING FEEDING RATE AND ADIPOSE TISSUE WEIGHT OF OBESITY ANIMAL
  申请人：Chen Ing-Jun

  公开号：US20130202549A1

  公开（公告）日：2013-08-08

  The disubstituted piperazine analogs (DPAs) derivative compound and DPAs amine complex compound disclosed in the present aspects have characterized by presented pharmaceutics having functions to improve lipolysis, such as inhibiting obesity hyperlipidemia, and atherosclerosis.

  本方面披露的二取代哌嗪类似物（DPAs）衍生物化合物和DPAs胺配合物化合物具有改善脂肪分解功能的特性，如抑制肥胖、高脂血症和动脉粥样硬化。
• SYNTHESIS AND PHARMACOKINETIC ACTIVITIES OF PULMODIL AND PULMODIL-1, TWO CHLOROPHENYLPIPERAZINE SALT DERIVATIVES
  申请人：Chen Ing-Jun

  公开号：US20100280040A1

  公开（公告）日：2010-11-04

  A compound including a salt derivative of the chlorophenylpiperazine moiety is provided, wherein the chlorophenylpiperazine moiety is derived from the reaction of a xanthine and a piperazine. The salt derivative thereof is non-toxic to the tracheal smooth muscle cells (TSMCs) and can be intravenously-, orally- or sublingually-dosed into the mammals.

  提供了一种化合物，其中包括氯苯哌嗪基团的盐衍生物，其中氯苯哌嗪基团是由黄嘌呤和哌嗪的反应衍生而来。其盐衍生物对气管平滑肌细胞（TSMCs）无毒，并可通过静脉、口服或舌下给药方式注入哺乳动物体内。
• PIPERAZINYL DERIVATIVE REDUCES HIGH-FAT DIET-INDUCED ACCUMULATION OF FAT IN THE LIVERS, THERAPEUTICALLY
  申请人：JANSFAT BIOTECHNOLOGY CO., LTD.

  公开号：US20150359798A1

  公开（公告）日：2015-12-17

  A method for inhibiting a liver disease is provided. The method includes administering a pharmaceutical composition of one of a piperazine analogue and a piperazine analogue complex to a warm-blooded animal suffering from the liver disease.

  提供了一种抑制肝病的方法。该方法包括向患有肝病的温血动物给予一种哌嗪类似物或哌嗪类似物复合物的制药组合物。
• METHOD FOR INHIBITING A LIVER DISEASE
  申请人：Jansfat Biotechnology Co., Ltd.

  公开号：EP2992885A2

  公开（公告）日：2016-03-09

  A method for inhibiting a liver disease is provided. The method includes administering a pharmaceutical composition of one of a piperazine analogue and a piperazine analogue complex to a warm-blooded animal suffering from the liver disease.

  提供了一种抑制肝病的方法。该方法包括向患有肝病的温血动物施用哌嗪类似物和哌嗪类似物复合物之一的药物组合物。
• Composition cosmétique stable contenant un glycéride d'acides gras, un alcool et un émulsionnant siliconé particulier
  申请人：L'ORÉAL

  公开号：EP1466589B1

  公开（公告）日：2008-12-17