N-methyl(3-trimethylsilyl)propylamine | 104272-57-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-methyl(3-trimethylsilyl)propylamine
• 英文别名: Methyl[3-(trimethylsilyl)propyl]amine；N-methyl-3-trimethylsilylpropan-1-amine
• CAS: 104272-57-3
• 化学式: C₇H₁₉NSi
• 分子量: 145.32
• InChiKey: GGESXPZQFPEEKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(1-(3,5-二甲基金刚烷基))苯基缩水甘油醚 、 N-methyl(3-trimethylsilyl)propylamine 以 异丙醇 为溶剂， 反应 16.0h， 生成 1-[4-(3,5-dimethyl-1-adamantyl)phenoxy]-3-[methyl(3-trimethylsilylpropyl)amino]propan-2-ol
  参考文献：
  名称：

  Identification of Promiscuous Small Molecule Activators in High-Throughput Enzyme Activation Screens

  摘要：

  It is recognized that high-throughput enzyme inhibition screens often return nonspecific inhibitors as. "hits". Recently, high-throughput screens for enzyme activators have led to the identification of several compounds with novel and potent biological activity. Here, we show that enzyme activation screens can also uncover compounds that activate multiple enzymes in a nonspecific fashion. Described herein are the general structural features of such compounds and methods to differentiate between specific and general enzyme activation.

  DOI：

  10.1021/jm701583b
• 作为产物：
  描述：

  (E)-3-trimethylsilyl-2-propenal 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N-methyl(3-trimethylsilyl)propylamine
  参考文献：
  名称：

  Surnin, V. A.; Stadnichuk, M. D., Journal of general chemistry of the USSR, 1985, vol. 55, # 9, p. 1822 - 1829

  摘要：

  DOI：

文献信息

• One-Pot Anti-Markovnikov Hydroamination of Unactivated Alkenes by Hydrozirconation and Amination
  作者：Alexandra E. Strom、John F. Hartwig

  DOI：10.1021/jo401498w

  日期：2013.9.6

  A one-pot anti-Markovnikov hydroamination of alkenes is reported. The synthesis of primary and secondary amines from unactivated olefins was accomplished in the presence of a variety of functional groups. Hydrozirconation, followed by amination with nitrogen electrophiles, provides exclusive anti-Markovnikov selectivity. Most products are isolated in high yields without the use of column chromatography

  报道了烯烃的一锅抗马尔科夫尼科夫加氢胺化反应。由未活化烯烃合成伯胺和仲胺是在各种官能团的存在下完成的。氢化锆，然后用氮亲电试剂胺化，提供独特的抗马尔科夫尼科夫选择性。大多数产品以高产率分离，无需使用柱层析。
• Identification of Promiscuous Small Molecule Activators in High-Throughput Enzyme Activation Screens
  作者：David R. Goode、Ryan K. Totten、James T. Heeres、Paul J. Hergenrother

  DOI：10.1021/jm701583b

  日期：2008.4.1

  It is recognized that high-throughput enzyme inhibition screens often return nonspecific inhibitors as. "hits". Recently, high-throughput screens for enzyme activators have led to the identification of several compounds with novel and potent biological activity. Here, we show that enzyme activation screens can also uncover compounds that activate multiple enzymes in a nonspecific fashion. Described herein are the general structural features of such compounds and methods to differentiate between specific and general enzyme activation.
• Surnin, V. A.; Stadnichuk, M. D., Journal of general chemistry of the USSR, 1985, vol. 55, # 9, p. 1822 - 1829
  作者：Surnin, V. A.、Stadnichuk, M. D.

  DOI：——

  日期：——