3-(4-aminomethyl[1,2,3]triazol-1-yl)propan-1-ol | 1101852-30-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(4-aminomethyl[1,2,3]triazol-1-yl)propan-1-ol
• 英文别名: 3-[4-(Aminomethyl)triazol-1-yl]propan-1-ol
• CAS: 1101852-30-5
• 化学式: C₆H₁₂N₄O
• 分子量: 156.187
• InChiKey: YPAMITHFYIQEKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-aminomethyl[1,2,3]triazol-1-yl)propan-1-ol 在 palladium 10% on activated carbon 、 氢气 、 三乙胺 作用下， 以 甲醇 、 戊醇 、 异丙醇 为溶剂， 60.0~145.0 ℃ 、101.33 kPa 条件下， 反应 61.0h， 生成 3-[4-(2-{[1-(3-hydroxypropyl)-1H-[1,2,3]triazol-4-ylmethyl]amino}-6-morpholin-4-yl-pyrimidin-4-ylamino)piperidin-1-yl]propionic acid methyl ester
  参考文献：
  名称：

  Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy

  摘要：

  DOI：

  10.1021/acs.jmedchem.1c01912
• 作为产物：
  描述：

  benzyl N-[[1-(3-hydroxypropyl)triazol-4-yl]methyl]carbamate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 异丙醇 为溶剂， 60.0 ℃ 、101.33 kPa 条件下， 反应 15.0h， 以93%的产率得到3-(4-aminomethyl[1,2,3]triazol-1-yl)propan-1-ol
  参考文献：
  名称：

  Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy

  摘要：

  DOI：

  10.1021/acs.jmedchem.1c01912

文献信息

• Click Chelators for Platinum‐Based Anticancer Drugs
  作者：Aurélie Maisonial、Patrycja Serafin、Mounir Traïkia、Eric Debiton、Vincent Théry、David J. Aitken、Pascale Lemoine、Bernard Viossat、Arnaud Gautier

  DOI：10.1002/ejic.200700849

  日期：2008.1

  Triazoles from “click chemistry” are convenient ligands for the formation of platinum complexes bearing combined triazole–amine or triazole–carboxylate moieties. Striking differences in the chelation modes are observed between the two series. One of the triazole–amine platinum complexes exhibits selective cytotoxicity against breast cancer cells lines. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim

  “点击化学”中的三唑是形成铂配合物的方便配体，该配合物带有组合的三唑-胺或三唑-羧酸盐部分。在两个系列之间观察到螯合模式的显着差异。其中一种三唑胺铂配合物对乳腺癌细胞系具有选择性细胞毒性。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• An ‘in-water’ halogen-ion compatible “click” catalyst for cucurbituril guest ligation
  作者：Hao Chen、Shengzhen Hou、Yebang Tan

  DOI：10.1080/10610278.2016.1142089

  日期：2016.10.2

  Most of the cucurbituril (CB) guests are water soluble cationic compounds with halogen counter-ions. Here, an in-water' halogen-ion compatible copper catalysed azide-alkyne cycloaddition (CuAAC) catalyst, tris[1-(3-hyroxypropyl)-1H-1,2,3-triazol-4-yl]methanolCuCl (THPTMCuCl), was designed for CB guest ligation. The catalyst demonstrates not only high catalytic activity, but also compatibility to cationic substrates, halogen-ions and free amino groups. A CB[8]-based star pseudo[5]rotaxane and a CB[7]-based main-chain alternative polypseudorotaxane were constructed using THPTMCuCl, which further verified its applicability for the construction of CB-based supramolecular architectures.
• "Click" Nanoparticle Conjugates
  申请人：Mirkin Chad A.

  公开号：US20120288935A1

  公开（公告）日：2012-11-15

  Modified nanoparticles are disclosed. More specifically, nanoparticles modified with an agent through a triazole linkage are disclosed. Also disclosed are methods of preparing modified nanoparticles and methods of using these modified nanoparticles.
• [EN] PYRIMIDINE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE PYRIMIDINE ET LEUR UTILISATION
  申请人：[en]YEH, Teng-Kuang

  公开号：WO2023014611A1

  公开（公告）日：2023-02-09

  Pyrimidine compounds of formula (I) shown herein. Also disclosed are pharmaceutical compositions containing one of the pyrimidine compounds and methods of using the pyrimidine compounds to treat or prevent chemotherapy- induced peripheral neuropathy.
• Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy
  作者：Yi-Fan Chen、Chien-Huang Wu、Li-Hsien Chen、Hao-Wei Lee、Jinq-Chyi Lee、Teng-Kuang Yeh、Jang-Yang Chang、Ming-Chen Chou、Hui-Ling Wu、Yen-Po Lai、Jen-Shin Song、Kai-Chia Yeh、Chiung-Tong Chen、Chia-Jui Lee、Kak-Shan Shia、Meng-Ru Shen

  DOI：10.1021/acs.jmedchem.1c01912

  日期：2022.3.24