disodium;3-[8-[(E)-2-(3-methoxyphenyl)ethenyl]-7-methyl-2,6-dioxo-1-prop-2-ynylpurin-3-yl]propyl phosphate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: disodium;3-[8-[(E)-2-(3-methoxyphenyl)ethenyl]-7-methyl-2,6-dioxo-1-prop-2-ynylpurin-3-yl]propyl phosphate
• 化学式: C21H21N4Na2O7P
• 分子量: 518.4
• InChiKey: ZYVZWCILYQDHNU-TTWKNDKESA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.05
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  140
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Antagonizing an adenosine A2A receptor to ameliorate one or more components of addictive behavior
  申请人：Diamond F. Ivan

  公开号：US20060128708A1

  公开（公告）日：2006-06-15

  This invention provides a method of mitigating/ameliorating one or more components of addictive behavior associated with chronic consumption of a substance of abuse, or withdrawal therefrom. The method typically involves administering to a subject in need thereof an adenosine A2A receptor antagonist in an amount sufficient to ameliorate said one or more components of addictive behavior.

  本发明提供了一种减轻/改善与长期服用或戒断滥用物质相关的一种或多种成瘾行为的方法。该方法通常包括向有需要的受试者施用腺苷 A2A 受体拮抗剂，其用量足以改善所述一种或多种成瘾行为。
• EP1765352A4
  申请人：——

  公开号：EP1765352A4

  公开（公告）日：2009-07-08
• ANTAGONIZING AN ADENOSINE A2A RECEPTOR TO AMELIORIATE ONE OR MORE COMPONENTS OF ADDICTIVE BEHAVIOR
  申请人：The Regents of the University of California

  公开号：EP1765352A2

  公开（公告）日：2007-03-28
• METHODS AND COMPOSITIONS FOR IMPROVING IMMUNE RESPONSES
  申请人：NorthEastern University

  公开号：EP2111231A2

  公开（公告）日：2009-10-28
• USE OF ADENOSINE A2A MODULATORS TO TREAT SPINAL CORD INJURY
  申请人：Li Jason Yuesheng

  公开号：US20080064653A1

  公开（公告）日：2008-03-13

  The present invention is a method for treatment or prevention of injury to nerve cells. The method can use at least one A 2A receptor modulator to prevent injury to or enhance the healing of the injured cells.