2-hydroxy-2-naphthylethyl acetate | 1256573-68-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-hydroxy-2-naphthylethyl acetate
• 英文别名: (2-Hydroxy-2-naphthalen-2-ylethyl) acetate；(2-hydroxy-2-naphthalen-2-ylethyl) acetate
• CAS: 1256573-68-8
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: KKXMMXYQPXWUAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙烯基萘 、 溶剂黄146 在 sodium periodate 、 copper(l) iodide 、 L-脯氨酸 作用下， 反应 18.0h， 以76%的产率得到2-hydroxy-2-naphthylethyl acetate
  参考文献：
  名称：

  CuI/l-proline-catalyzed selective one-step mono-acylation of styrenes and stilbenes

  摘要：

  Vicinal di-oxygenation of styrene-type olefins was achieved with cheaper, less toxic Cul in the presence of L-proline as ligand and NalO(4) as the oxidant. This approach provides a straightforward and efficient access to mono-acylated diols from both styrene and stilbene derivatives with good to excellent yields and diastereoselectivity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.084

文献信息

• CuI/l-proline-catalyzed selective one-step mono-acylation of styrenes and stilbenes
  作者：P. Sai Prathima、C. Uma Maheswari、K. Srinivas、M. Mohan Rao

  DOI：10.1016/j.tetlet.2010.08.084

  日期：2010.11

  Vicinal di-oxygenation of styrene-type olefins was achieved with cheaper, less toxic Cul in the presence of L-proline as ligand and NalO(4) as the oxidant. This approach provides a straightforward and efficient access to mono-acylated diols from both styrene and stilbene derivatives with good to excellent yields and diastereoselectivity. (C) 2010 Elsevier Ltd. All rights reserved.