8-({[4-amino-6-(piperidin-1-yl)-1,3,5-triazin-2-yl]methyl}sulfanyl)-7-ethyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-({[4-amino-6-(piperidin-1-yl)-1,3,5-triazin-2-yl]methyl}sulfanyl)-7-ethyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• 英文别名: 8-[(4-amino-6-piperidin-1-yl-1,3,5-triazin-2-yl)methylsulfanyl]-7-ethyl-1,3-dimethylpurine-2,6-dione
• 化学式: C₁₈H₂₅N₉O₂S
• mdl: MFCD03036171
• 分子量: 431.5
• InChiKey: SMKOFGXMPGXZIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  152
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions
  申请人：BAR ILAN UNIVERSITY

  公开号：US11123339B2

  公开（公告）日：2021-09-21

  The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods and uses thereof in innate and acquired immune-related disorders or conditions, specifically, in primary and secondary immune-deficiencies.

  本发明提供了调节威斯科特-阿尔德里奇综合征蛋白（WASp）降解和稳定性的特异性小分子化合物及其在先天性和获得性免疫相关疾病或病症中的方法和用途，特别是在原发性和继发性免疫缺陷中的方法和用途。
• WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS
  申请人：BAR ILAN UNIVERSITY

  公开号：US20190216794A1

  公开（公告）日：2019-07-18

  The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods and uses thereof in innate and acquired immune-related disorders or conditions, specifically, in primary and secondary immune-deficiencies.
• [EN] WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS<br/>[FR] PETITES MOLÉCULES DE PROTECTION DE WASP, COMPOSITIONS, PROCÉDÉS ET UTILISATIONS DE CELLES-CI DANS LE TRAITEMENT DE TROUBLES OU D'ÉTATS LIÉS À L'IMMUNITÉ INNÉE ET ACQUISE
  申请人：UNIV BAR ILAN

  公开号：WO2018055627A1

  公开（公告）日：2018-03-29

  The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods and uses thereof in innate and acquired immune-related disorders or conditions, specifically, in primary and secondary immune-deficiencies.