Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH(2)

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH(2)
• 英文别名: (4S)-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoic acid
• 化学式: C₇₆H₁₀₉N₂₁O₁₈
• 分子量: 1604.8
• InChiKey: JNJRHFMBJXNFRD-PVTUMTKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  115
• 可旋转键数：
  49
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  642
• 氢给体数：
  22
• 氢受体数：
  22

文献信息

• COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTION AND/OR TREATMENT OF CANCER
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP3471722A1

  公开（公告）日：2019-04-24
• [EN] TREATMENT OF CARDIAC ARRHYTHMIAS<br/>[FR] TRAITEMENT D'ARYTHMIES CARDIAQUES
  申请人：UNIV ERASMUS MED CT ROTTERDAM

  公开号：WO2016195476A1

  公开（公告）日：2016-12-08

  The present invention is directed to a pharmaceutical combination comprising amiodarone and afamelanotide, to methods for symptomatic or prophylactic treatment of amiodarone-induced photosensitivity and/or cytotoxicity in a subject suffering from cardiac arrhythmia, to methods for the prophylactic treatment of amiodarone- induced photosensitivity and/or cytotoxicity in an amiodarone recipient suffering from cardiac arrhythmia and predisposed to amiodarone-induced photosensitivity and/or cytotoxicity, and to further medical uses of afamelanotide in the treatment of cardiac arrhythmia and predisposed to amiodarone-induced photosensitivity and/or cytotoxicity.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTION AND/OR TREATMENT OF CANCER<br/>[FR] COMPOSÉS ET MÉTHODES POUR LA PRÉVENTION ET/OU LE TRAITEMENT DU CANCER
  申请人：UNIV PENNSYLVANIA

  公开号：WO2017218191A1

  公开（公告）日：2017-12-21

  The present invention includes compounds, compositions and methods that are useful for preventing or treating melanoma or any other Myc-expressing cancer in a subject. In certain embodiments, the compounds comprise estrogen (including estrogen derivatives or analogues), a selective GPER agonist and/or another small molecule G-protein coupled receptor (GPCR) agonist that increases cancer cell differentiation.