2-(1-fluoroethyl)thieno[2,3-g]isoquinoline-4,9-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-(1-fluoroethyl)thieno[2,3-g]isoquinoline-4,9-dione
• 英文别名: 2-(1-fluoroethyl)thieno[2,3-g]isoquinolin-4,9-dione；2-(1-Fluoroethyl)thieno[2,3-g]isoquinoline-4,9-dione
• 化学式: C₁₃H₈FNO₂S
• 分子量: 261.276
• InChiKey: MLGIYWWYVHRRHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  75.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NEW TRICYCLIC QUINONE DERIVATIVE
  申请人：Boston Biomedical, Inc

  公开号：US20170015677A1

  公开（公告）日：2017-01-19

  This invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof [Therein, A is O, S, or N—R 6 ; ring G is a 5-membered or 6-membered aromatic ring, etc., including 1-3 heteroatoms selected from O, S and N as constituent atoms; R 1 and R 2 are each independently a hydrogen atom, a halogen atom, or an optionally-substituted C 1-6 alkyl carbonyl group, etc.; R 3 , R 4 and R 5 are each independently a hydrogen atom, a halogen atom, or an optionally-substituted C 1-6 alkyl carbonyl group, etc.; and R 6 is a hydrogen atom or an optionally-substituted C 1-6 alkyl group, etc.].

  这项发明提供了由式（1）表示的化合物或其药学上可接受的盐。具体来说，本发明提供了由式（1）表示的化合物或其药学上可接受的盐【其中，A为O、S或N—R6；环G为5-元环或6-元芳香环等，包括1-3个选自O、S和N的杂原子作为成分原子；R1和R2各自独立地是氢原子、卤素原子或一个可选择取代的C1-6烷基羰基基团等；R3、R4和R5各自独立地是氢原子、卤素原子或一个可选择取代的C1-6烷基羰基基团等；R6是一个氢原子或一个可选择取代的C1-6烷基基团等】。
• Tricyclic quinone derivative
  申请人：Boston Biomedical, Inc.

  公开号：US10934309B2

  公开（公告）日：2021-03-02

  This invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof [Therein, A is O, S, or N—R6; ring G is a 5-membered or 6-membered aromatic ring, etc., including 1-3 heteroatoms selected from O, S and N as constituent atoms; R1 and R2 are each independently a hydrogen atom, a halogen atom, or an optionally-substituted C1-6 alkyl carbonyl group, etc.; R3, R4 and R5 are each independently a hydrogen atom, a halogen atom, or an optionally-substituted C1-6 alkyl carbonyl group, etc.; and R6 is a hydrogen atom or an optionally-substituted C1-6 alkyl group, etc.].

  本发明提供了一种由式（1）代表的化合物或其药学上可接受的盐。具体地说，本发明提供了一种由式（1）代表的化合物或其药学上可接受的盐[其中，A 是 O、S 或 N-R6；环 G 是 5 元或 6 元芳香环等、其中，A 是 O、S 或 N-R6；环 G 是 5 元或 6 元芳香环等，包括 1-3 个选自 O、S 和 N 的杂原子作为组成原子；R1 和 R2 各自独立地是氢原子、卤素原子或任选取代的 C1-6 烷基羰基等；R3、R4 和 R5 各自独立地是氢原子、卤素原子或任选取代的 C1-6 烷基羰基等；R6 是氢原子或任选取代的 C1-6 烷基等]。