Imidazo[1,2-a]pyridin-3-amine, 2-(6-methoxy-3-pyridinyl)-8-methyl- | 1610586-26-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: Imidazo[1,2-a]pyridin-3-amine, 2-(6-methoxy-3-pyridinyl)-8-methyl-
• 英文别名: 2-(6-methoxypyridin-3-yl)-8-methylimidazo[1,2-a]pyridin-3-amine
• CAS: 1610586-26-9
• 化学式: C₁₄H₁₄N₄O
• 分子量: 254.29
• InChiKey: PZDHDAYQUHYBRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  65.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
  申请人：ARRAY BIOPHARMA INC.

  公开号：US20160355517A1

  公开（公告）日：2016-12-08

  Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
• US9822118B2
  申请人：——

  公开号：US9822118B2

  公开（公告）日：2017-11-21