3-Ethyl-1-methyl-7,9-dihydropurine-2,6,8-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-Ethyl-1-methyl-7,9-dihydropurine-2,6,8-trione
• 化学式: C₈H₁₀N₄O₃
• 分子量: 210.19
• InChiKey: YJGXHNVGJWIVEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Materials and methods for binding nucleic acids to surfaces
  申请人：——

  公开号：US20020103350A1

  公开（公告）日：2002-08-01

  Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By masking the phosphate charges of the nucleic acids, undesired interactions may be minimized or eliminated, thereby allowing the covalent bonding of the nucleic acids to the surface to proceed. The use of such formulations additionally minimizes nonspecific binding of the nucleic acids to the surface. Examples of materials to be included in such formulations include cations, xanthines, hexoses, purines, arginine, lysine, polyarginine, polylysine, and quaternary ammonium salts.

  含有高纯度二氧化硅的表面具有很高的核酸负载潜力。 本研究公开了含有核酸的制剂和可掩盖核酸与表面之间静电相互作用的材料。通过掩盖核酸的磷酸电荷，可以最大限度地减少或消除不希望发生的相互作用，从而使核酸与表面的共价键结合得以进行。此外，使用此类制剂还能最大程度地减少核酸与表面的非特异性结合。可包括在此类制剂中的材料包括阳离子、黄嘌呤、己糖、嘌呤、精氨酸、赖氨酸、多精氨酸、多赖氨酸和季铵盐。
• MATERIALS AND METHODS FOR BINDING NUCLEIC ACIDS TO SURFACES
  申请人：Lyles, Mark B.

  公开号：EP1305328A2

  公开（公告）日：2003-05-02
• US6855817B2
  申请人：——

  公开号：US6855817B2

  公开（公告）日：2005-02-15
• US7247721B2
  申请人：——

  公开号：US7247721B2

  公开（公告）日：2007-07-24
• [EN] MATERIALS AND METHODS FOR BINDING NUCLEIC ACIDS TO SURFACES<br/>[FR] MATERIELS ET METHODES DE FIXATION D'ACIDES NUCLEIQUES A DES SURFACES
  申请人：LYLES MARK B

  公开号：WO2002008237A2

  公开（公告）日：2002-01-31

  Surfaces contaning high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By masking the phosphate charges of the nucleic acids, undersired interactions may be minimized or eliminated, thereby allowing the covalent boding of the nucleic acids to the surface to proceed. The use of such formulations additionally minimizes nonspecific binding of the nucleic acids to the surface. Examples of materials to be included in such formulations include cations, xanthines, hexoses, purines, arginine, lysine, polyarginine, polylysine, and quaternary ammonium salts.