N-cyclohexyl-3-phenyl-4H-1,4-benzoxazin-2-amine | 1194524-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: N-cyclohexyl-3-phenyl-4H-1,4-benzoxazin-2-amine
• CAS: 1194524-78-1
• 化学式: C₂₀H₂₂N₂O
• 分子量: 306.407
• InChiKey: PQNBOLLERRXKLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异氰环已烷 、 苯甲醛 、 2-氨基苯酚 在 1-丁基-3-甲基咪唑溴盐 作用下， 反应 12.0h， 以94%的产率得到N-cyclohexyl-3-phenyl-4H-1,4-benzoxazin-2-amine
  参考文献：
  名称：

  Three-Component, One-Pot Synthesis of Benzo[b][1,4]oxazines in Ionic Liquid 1-Butyl-3-methylimidazolium Bromide

  摘要：

  Benzo[b][1,4]oxazines have been synthesized in good to excellent yields in the presence of the ionic liquid 1-butyl-3-methylimidazolium bromide [bmim]Br under relatively mild conditions without any added catalyst, The method offers the advantages of good yields and short reaction times, and the ionic liquid can be easily separated from the product and reused.

  DOI：

  10.1080/00397911.2010.540056

文献信息

• Three-Component, One-Pot Synthesis of Benzo[<i>b</i>][1,4]oxazines in Ionic Liquid 1-Butyl-3-methylimidazolium Bromide
  作者：Ebrahim Soleimani、Mohammad Mehdi Khodaei、Afsaneh Taheri Kal Koshvandi

  DOI：10.1080/00397911.2010.540056

  日期：2012.5.1

  Benzo[b][1,4]oxazines have been synthesized in good to excellent yields in the presence of the ionic liquid 1-butyl-3-methylimidazolium bromide [bmim]Br under relatively mild conditions without any added catalyst, The method offers the advantages of good yields and short reaction times, and the ionic liquid can be easily separated from the product and reused.