8,9,10,12-tetrahydro-2-methoxy-9,9-dimethyl-12-phenyl-11H-benzo[a]xanthen-11-one | 1355365-78-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 8,9,10,12-tetrahydro-2-methoxy-9,9-dimethyl-12-phenyl-11H-benzo[a]xanthen-11-one
• 英文别名: 2-methoxy-9,9-dimethyl-12-phenyl-10,12-dihydro-8H-benzo[a]xanthen-11-one
• CAS: 1355365-78-4
• 化学式: C₂₆H₂₄O₃
• 分子量: 384.475
• InChiKey: XLKOVONZUOCGKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-甲氧基-2-萘 、 苯甲醛 、 5,5-二甲基-1,3-环己二酮 在 scandium tris(trifluoromethanesulfonate) 作用下， 反应 0.08h， 以90%的产率得到8,9,10,12-tetrahydro-2-methoxy-9,9-dimethyl-12-phenyl-11H-benzo[a]xanthen-11-one
  参考文献：
  名称：

  Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[a]xanthen-11-ones

  摘要：

  Synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-ones was achieved by one-pot condensation of beta-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds catalyzed by Sc(OTf)(3) under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity.

  DOI：

  10.1007/s00706-011-0577-4

文献信息

• Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[a]xanthen-11-ones
  作者：Madharam Sudershan Rao、Bhupender S. Chhikara、Rakesh Tiwari、Amir N. Shirazi、Keykavous Parang、Anil Kumar

  DOI：10.1007/s00706-011-0577-4

  日期：2012.2

  Synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-ones was achieved by one-pot condensation of beta-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds catalyzed by Sc(OTf)(3) under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity.