H-DL-Bpa-DL-Ser-DL-Trp-DL-Ser-DL-Phe(F5)-DL-Cha-DL-Arg-DL-Arg-DL-Arg-DL-Gln-DL-Arg-DL-Arg-OH

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: H-DL-Bpa-DL-Ser-DL-Trp-DL-Ser-DL-Phe(F5)-DL-Cha-DL-Arg-DL-Arg-DL-Arg-DL-Gln-DL-Arg-DL-Arg-OH
• 英文别名: 2-[[2-[[5-amino-2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-amino-3-(4-benzoylphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(2,3,4,5,6-pentafluorophenyl)propanoyl]amino]-3-cyclohexylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
• 化学式: C₈₆H₁₂₂F₅N₂₉O₁₇
• 分子量: 1929.1
• InChiKey: DEZJGRPRBZSAKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  137
• 可旋转键数：
  63
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  809
• 氢给体数：
  32
• 氢受体数：
  28

文献信息

• PEPTIDES AND PEPTIDOMIMETICS IN COMBINATION WITH T CELL ACTIVATING AND/OR CHECKPOINT INHIBITING AGENTS FOR CANCER TREATMENT
  申请人：CanBas Co., Ltd.

  公开号：US20170112894A1

  公开（公告）日：2017-04-27

  This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells, and combinations of T cell activating agents and/or an immune checkpoint inhibitors with and without peptides and peptidomimetics. The invention compounds and combinations can be used to inhibit cell growth, such as treat a tumor or cancer.