7-溴-4-氯噻吩并[3,2-C]吡啶 | 29064-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 中文名称: 7-溴-4-氯噻吩并[3,2-C]吡啶
• 中文别名: 7-溴-4-氯-噻吩并[3,2-c]吡啶
• 英文名称: 7-Brom-4-chlor-thieno-<3,2-c>-pyridin
• 英文别名: 7-Bromo-4-chlorothieno[3,2-c]pyridine
• CAS: 29064-76-4
• 化学式: C₇H₃BrClNS
• 分子量: 248.531
• InChiKey: AXJKCXXTMCUWLS-UHFFFAOYSA-N

物化性质

• 沸点：
  332.9±37.0 °C(Predicted)
• 密度：
  1.849

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY
  申请人：Board of Regents,The University of Texas System

  公开号：EP1409491A2

  公开（公告）日：2004-04-21
• SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Relay Therapeutics, Inc.

  公开号：EP3768668A1

  公开（公告）日：2021-01-27
• [EN] THIENOPYRIMIDINE-BASED INHIBITORS OF THE SRC FAMILY<br/>[FR] INHIBITEURS DE LA FAMILLE SRC A BASE DE THIENOPYRIMIDINE
  申请人：UNIV TEXAS

  公开号：WO2002057271A2

  公开（公告）日：2002-07-25

  Various thienopyrimidine-based analog compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections. Embodiments of the invention are compounds of the formulae (A),(B) and (C)
• [EN] SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE LA PHOSPHATASE SHP2 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：RELAY THERAPEUTICS INC

  公开号：WO2019183367A1

  公开（公告）日：2019-09-26

  The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.