4-Amino-N~3~-(1,3-dioxo-2,3-dihydro-1H-isoindol-5-YL)-1-methyl-1H-pyrazole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4-Amino-N~3~-(1,3-dioxo-2,3-dihydro-1H-isoindol-5-YL)-1-methyl-1H-pyrazole-3-carboxamide
• 英文别名: 4-amino-N-(1,3-dioxoisoindol-5-yl)-1-methylpyrazole-3-carboxamide
• 化学式: C₁₃H₁₁N₅O₃
• 分子量: 285.26
• InChiKey: MYHCNTBNOPKYRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Phthalimide compounds useful as protein kinase inhibitors
  申请人：Green Jeremy

  公开号：US20050182061A1

  公开（公告）日：2005-08-18

  The present invention provides compounds as inhibitors of protein kinase, particularly inhibitors of AKT, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides processes for preparing the compounds of the invention, pharmaceutical compositions comprising the compounds, and methods of utilizing those compounds and compositions in the treatment of various disorders.

  本发明提供了作为蛋白激酶抑制剂的化合物，特别是AKT、PDK1、p70S6K或ROCK激酶的抑制剂，这些哺乳动物蛋白激酶参与了增殖性和神经退行性疾病。本发明还提供了制备本发明化合物的工艺、包含本发明化合物的药物组合物，以及利用这些化合物和组合物治疗各种疾病的方法。
• [EN] PHTHALIMIDE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS<br/>[FR] COMPOSES PHTALIMIDE UTILES EN TANT QU'INHIBITEURS DE PROTEINE KINASE
  申请人：VERTEX PHARMA

  公开号：WO2005039564A1

  公开（公告）日：2005-05-06

  The present invention provides compounds of formula I as inhibitors of protein kinase, particularly inhibitors of AKT, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides processes for preparing the compounds of the invention, pharmaceutical compositions comprising the compounds, and methods of utilizing those compounds and compositions in the treatment of various disorders.