7-溴-5-甲基-1-苯并呋喃 | 35700-48-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 7-溴-5-甲基-1-苯并呋喃
• 中文别名: 7-溴-5-甲基苯并[B]呋喃；7-溴-5-甲基苯并
• 英文名称: 7-bromo-5-methylbenzofuran
• 英文别名: 7-Bromo-5-methyl-1-benzofuran
• CAS: 35700-48-2
• 化学式: C₉H₇BrO
• 分子量: 211.058
• InChiKey: TZUMDTURHSPEAY-UHFFFAOYSA-N

物化性质

• 沸点：
  259.7±20.0 °C(Predicted)
• 密度：
  1.520±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2932999099
• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  7-溴-5-甲基-1-苯并呋喃 在 tris-(dibenzylideneacetone)dipalladium(0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 三氟乙酸 、 sodium t-butanolate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 12.0h， 生成 5-methyl-7-(piperazino)benzo[b]furan
  参考文献：
  名称：

  Synthesis of piperazino-substituted benzo[b]furans as potential CNS agents

  摘要：

  The synthesis of a series of substituted benzofurans is reported. Selected compounds have been shown to bind strongly and with high selectivity to the serotonin receptor 5-HT2A in the presence of the receptor 5-HT7 in vitro.

  DOI：

  10.1515/hc.2010.009
• 作为产物：
  描述：

  2-溴-(2,2-二甲氧基-乙氧基)-4-甲基苯 在 4-碘-2-甲基苯酚 、 ethyl acetate n-hexane 作用下， 以 氯苯 为溶剂， 反应 2.0h， 以Column chromatography (10% EtOAc/hexane) afforded 11.54 g (66%) of product as a clear oil的产率得到7-溴-5-甲基-1-苯并呋喃
  参考文献：
  名称：

  Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents

  摘要：

  这项发明提供了具有以下结构的雌激素受体调节剂，其中R1-R5如规范中所定义；或其药学上可接受的盐。

  公开号：

  US20050009907A1

文献信息

• [EN] QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION<br/>[FR] COMPOSÉ DE QUINOLONE ET AGENT PHARMACEUTIQUE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2010064735A1

  公开（公告）日：2010-06-10

  The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein: R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 represents substituted or unsubstituted phenyl or the like; R4 represents halogen or the like; R5 represents hydrogen or the like; R6 represents hydrogen or the like; and R7 represents hydrogen or the like.

  本发明提供了一种喹诺酮化合物，该化合物能够抑制帕金森病的慢性进展或保护多巴胺神经元免受疾病病因的影响，从而抑制神经功能障碍的进展，以便在延长给予L-多巴的时间的同时改善神经元功能；本发明的喹诺酮化合物由公式(1)表示：其中：R1代表氢等；R2代表氢等；R3代表取代或未取代的苯基等；R4代表卤素等；R5代表氢等；R6代表氢等；R7代表氢等。
• QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION
  申请人：Otsubo Kenji

  公开号：US20110269705A1

  公开（公告）日：2011-11-03

  The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein: R 1 represents hydrogen or the like; R 2 represents hydrogen or the like; R 3 represents substituted or unsubstituted phenyl or the like; R 4 represents halogen or the like; R 5 represents hydrogen or the like; R 6 represents hydrogen or the like; and R 7 represents hydrogen or the like.

  本发明提供了一种喹诺酮化合物，用于抑制帕金森病的慢性进展或保护多巴胺神经元免受疾病病因的影响，从而抑制神经功能障碍的进展，延长L-多巴胺治疗之前的时间，并改善神经元功能；本发明的喹诺酮化合物由式（1）表示：其中：R1代表氢或类似物；R2代表氢或类似物；R3代表取代或未取代的苯基或类似物；R4代表卤素或类似物；R5代表氢或类似物；R6代表氢或类似物；R7代表氢或类似物。
• Quinolone compound and pharmaceutical composition
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US08304546B2

  公开（公告）日：2012-11-06

  The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein: R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 represents substituted or unsubstituted phenyl or the like; R4 represents halogen or the like; R5 represents hydrogen or the like; R6 represents hydrogen or the like; and R7 represents hydrogen or the like.

  本发明提供了一种喹诺酮化合物，该化合物能够抑制帕金森病的慢性进展或保护多巴胺神经元免受疾病病因的影响，从而抑制神经功能障碍的进展，延长L-多巴胺治疗之前的时间，同时改善神经元功能；本发明的喹诺酮化合物由式（1）表示：其中：R1代表氢或类似物；R2代表氢或类似物；R3代表取代或未取代的苯基或类似物；R4代表卤素或类似物；R5代表氢或类似物；R6代表氢或类似物；R7代表氢或类似物。
• [EN] TREATMENT OF MYC-DRIVEN CANCERS WITH GSPT1 DEGRADERS<br/>[FR] TRAITEMENT DE CANCERS ENTRAÎNÉS PAR MYC AVEC DES AGENTS DE DÉGRADATION GSPT1
  申请人：MONTE ROSA THERAPEUTICS AG

  公开号：WO2022152822A1

  公开（公告）日：2022-07-21

  The present disclosure relates to new methods to predict the responsiveness of cancer patients to GSPT1 negative modulators and thus determine the of efficacy GSPT1 negative modulators to treat cancer patients by determining the level of one or more biomarkers in samples of the patients. The present disclosure also relates to applications of these methods, which includes stratifying cancer malignancies, in particular identifying myc-driven cancers, and thereby devising optimized and personalized treatments for these cancer patients, as well as optimizing the selection of patient populations for respective clinical trials.

  本公开涉及新的方法来预测癌症患者对GSPT1负调节剂的反应性，从而通过确定患者样本中一个或多个生物标志物的水平来确定GSPT1负调节剂治疗癌症患者的有效性。本公开还涉及这些方法的应用，包括分层癌症恶性程度，特别是识别驱动肿瘤的myc，从而为这些癌症患者设计优化和个性化的治疗方案，以及优化选择患者人群进行相应的临床试验。
• [EN] ISOINDOLINONE COMPOUNDS<br/>[FR] COMPOSÉS D'ISOINDOLINONE
  申请人：MONTE ROSA THERAPEUTICS AG

  公开号：WO2022152821A1

  公开（公告）日：2022-07-21

  Disclosed herein are compound or pharmaceutically acceptable salts or stereoisomers thereof of formula (I). These compounds find use as modulators of cereblon, in particular in the treatment of abnormal cell growth in mammals, especially humans.

  本文揭示了公式(I)的化合物或药学上可接受的盐或其立体异构体。这些化合物可用作 cereblon 调节剂，特别是用于治疗哺乳动物，尤其是人类的异常细胞生长。