6-Chloro-imidazo[1,2-a]pyridin-2-one; hydrobromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6-Chloro-imidazo[1,2-a]pyridin-2-one; hydrobromide
• 英文别名: 6-chloro-3H-imidazo[1,2-a]pyridin-2-one;hydrobromide
• 化学式: BrH*C₇H₅ClN₂O
• 分子量: 249.494
• InChiKey: GKMWVMXUVVFPFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.45
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-amino-5-chloro-1-(2-ethoxy-2-oxoethyl)-pyridin-1-ium bromide 以 乙醇 为溶剂， 反应 2.0h， 以85%的产率得到6-Chloro-imidazo[1,2-a]pyridin-2-one; hydrobromide
  参考文献：
  名称：

  An Improved Synthesis of 2-Chlorinated Imidazo[1,2-α]-pyridines and the Application of this Procedure for the Synthesis of Several New Polychlorinated Imidazo[1,2-α]Pyridnes.

  摘要：

  Polychlorinated imidazo[1,2-a]pyridines were synthesized as analogs of certain chlorinated benzimidazoles. The imidazo[1,2-a]pyridines were obtained by a condensation of ethyl bromoacetate and chlorinated 2-aminopyridines. These condensation products were treated with an ion exchange resin to effect an exchange of hydrobromide salts with hydrochloride salts. These compounds were subsequently treated with POCl3 to convert the imidazo[1,2-a]pyridin-2-ones into 2-chloroimidazo[1,2-a]pyridines.

  DOI：

  10.1080/00397919708004089