2-benzyloxynaphthalen-1-yl formate | 330581-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-benzyloxynaphthalen-1-yl formate
• CAS: 330581-76-5
• 化学式: C₁₈H₁₄O₃
• 分子量: 278.307
• InChiKey: RHVCUZWGEXYKGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-benzyloxynaphthalen-1-yl formate 在 sodium hydroxide 、 sodium dithionite 作用下， 以 甲醇 为溶剂， 以75%的产率得到2-Benzyloxy-1-naphthol
  参考文献：
  名称：

  Kral, Andreas; Laatsch, Hartmut, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1993, vol. 48, # 10, p. 1401 - 1407

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苄氧基-1-萘醛 在 过氧乙酸 作用下， 以 乙酸乙酯 为溶剂， 以80%的产率得到2-benzyloxynaphthalen-1-yl formate
  参考文献：
  名称：

  2-Alkoxyarenol-derived orthoquinols in carbon–oxygen, carbon–nitrogen and carbon–carbon bond-forming reactions

  摘要：

  Silylated oxygen- and nitrogen-tethered orthoquinol acetates, generated by phenyliodine(III) diacetoxy-mediated oxidative acetoxylation of 2-alkoxyphenols in CH2Cl2 can be used to furnish regioselectively benzannulated heterocycles. Oxidative activation of 2-alkoxynaphthols with non-nucleophilic phenyliodine(III) bis(trifluoroacetoxy) in the presence of carbon nucleophiles, including oxidation sensitive silyl enol ethers, constitute a potentially valuable route to naturally occurring vicinally oxygenated benz[a]anthracene motifs. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00939-x

文献信息

• Kral, Andreas; Laatsch, Hartmut, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1993, vol. 48, # 10, p. 1401 - 1407
  作者：Kral, Andreas、Laatsch, Hartmut

  DOI：——

  日期：——
• 2-Alkoxyarenol-derived orthoquinols in carbon–oxygen, carbon–nitrogen and carbon–carbon bond-forming reactions
  作者：Stéphane Quideau、Laurent Pouységu、Mayalen Oxoby、Matthew A Looney

  DOI：10.1016/s0040-4020(00)00939-x

  日期：2001.1

  Silylated oxygen- and nitrogen-tethered orthoquinol acetates, generated by phenyliodine(III) diacetoxy-mediated oxidative acetoxylation of 2-alkoxyphenols in CH2Cl2 can be used to furnish regioselectively benzannulated heterocycles. Oxidative activation of 2-alkoxynaphthols with non-nucleophilic phenyliodine(III) bis(trifluoroacetoxy) in the presence of carbon nucleophiles, including oxidation sensitive silyl enol ethers, constitute a potentially valuable route to naturally occurring vicinally oxygenated benz[a]anthracene motifs. (C) 2000 Elsevier Science Ltd. All rights reserved.