2,2'-ethanediyl-bis-benz[de]isoquinoline-1,3-dione | 94887-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2,2'-ethanediyl-bis-benz[de]isoquinoline-1,3-dione
• 英文别名: 2,2'-Aethandiyl-bis-benz[de]isochinolin-1,3-dion；2-[2-(1,3-Dioxobenzo[de]isoquinolin-2-yl)ethyl]benzo[de]isoquinoline-1,3-dione
• CAS: 94887-59-9
• 化学式: C₂₆H₁₆N₂O₄
• 分子量: 420.424
• InChiKey: HTRRKQZXJVTCFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,8-萘二甲酸酐 、 乙二胺 在 Shellsol A 作用下， 反应 3.0h， 以74%的产率得到2,2'-ethanediyl-bis-benz[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Vitrigens. I. Synthesis and Characterization of Low Molecular Weight Organic Glasses

  摘要：

  New low molecular weight organic materials with a strong tendency towards glass formation and glass temperatures above room temperature were synthesized. These materials consist of twin molecules where two bulky groups, i.e. carbazole (Ca), 3,6-dibromocarbazole (DBrCa), 2,3-benzocarbazole (BC), 1,2-benzo-3,4-dihydrocarbazole (BCDH), phenothiazine (Ph), 1,8-naphthalic acid anhydride (NI), and pyrene-l-aldehyde (PY) have been linked by flexible or semiflexible aliphatic or aromatic central units. Their structure-glass temperature relationship and some relations between thermodynamic parameters and amorphous properties are discussed.

  DOI：

  10.1002/(sici)1521-3897(199902)341:2<128::aid-prac128>3.0.co;2-m

文献信息

• 10.1021/acs.analchem.4c01945
  作者：Feng, Beidou、Wang, Zhe、Zhao, Xiaoli、Niu, Huiyu、Wang, Yafu、Wang, Kui、Jiang, Kai、Zhang, Hua

  DOI：10.1021/acs.analchem.4c01945

  日期：——

  These probes emit the red fluorescence around 627 nm with different fluorescence quantum yields (ΦNAN0-OH = 0.0016, ΦNAN2-OH = 0.0136, and ΦNAN6-OH = 0.0125). When encountering mtDNA (0.4–3.4 μg/mL), these probes undergo conformational changes depending on the length of the attached C-strand and exhibit a gradually increasing fluorescence signal around 453 nm. The fluorescence intensity increased to 13

  线粒体DNA（mtDNA）是一种以母系遗传为特征的独特遗传物质。它具有缺乏组蛋白保护的圆形结构，并且细胞丰度较低，这对其在活细胞水平上的灵敏和选择性检测提出了巨大的挑战。在这里，我们设计了三种具有不同接头长度的双萘酰亚胺探针（NANn-OH，n = 0,2,6），促进在自由状态下形成不同的扭曲或折叠分子构象。这些探针发射约 627 nm 的红色荧光，具有不同的荧光量子产率（Φ NAN0-OH = 0.0016、Φ NAN2-OH = 0.0136 和 Φ NAN6-OH = 0.0125）。当遇到 mtDNA (0.4–3.4 μg/mL) 时，这些探针会根据所附着的 C 链长度发生构象变化，并在 453 nm 附近表现出逐渐增强的荧光信号。荧光强度分别增加至13.5倍、1.9倍和8.2倍。值得注意的是，627 nm 附近的红色荧光强度在整个过程中保持恒定，从而作为比例荧光信号增强的固有校正机制，以提高选择性和灵敏度。
• Über die Darstellung von Naphthoylen-imidazolinen
  作者：Hans Eduard Fierz-David、Carlo Rossi

  DOI：10.1002/hlca.193802101182

  日期：——
• Vitrigens. I. Synthesis and Characterization of Low Molecular Weight Organic Glasses
  作者：D. Braun、R. Langendorf

  DOI：10.1002/(sici)1521-3897(199902)341:2<128::aid-prac128>3.0.co;2-m

  日期：1999.2

  New low molecular weight organic materials with a strong tendency towards glass formation and glass temperatures above room temperature were synthesized. These materials consist of twin molecules where two bulky groups, i.e. carbazole (Ca), 3,6-dibromocarbazole (DBrCa), 2,3-benzocarbazole (BC), 1,2-benzo-3,4-dihydrocarbazole (BCDH), phenothiazine (Ph), 1,8-naphthalic acid anhydride (NI), and pyrene-l-aldehyde (PY) have been linked by flexible or semiflexible aliphatic or aromatic central units. Their structure-glass temperature relationship and some relations between thermodynamic parameters and amorphous properties are discussed.