7-羟基吩噻嗪-3-酮 | 3568-81-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 7-羟基吩噻嗪-3-酮
• 英文名称: thionol
• 英文别名: 3H-Phenothiazin-3-one, 7-hydroxy-；7-hydroxyphenothiazin-3-one
• CAS: 3568-81-8
• 化学式: C₁₂H₇NO₂S
• 分子量: 229.259
• InChiKey: GSEOMGSFLQCKRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934300000

反应信息

• 作为反应物：
  描述：

  7-羟基吩噻嗪-3-酮 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Bernthsen, Justus Liebigs Annalen der Chemie, 1885, vol. 230, p. 169,170

  摘要：

  DOI：
• 作为产物：
  描述：

  2-amino-5-dimethylaminophenylthiosulphonic acid 在 sodium hydroxide 、 sodium hypochlorite 作用下， 生成 7-羟基吩噻嗪-3-酮
  参考文献：
  名称：

  Heller, Journal fur praktische Chemie (Leipzig 1954), 1924, vol. <2> 108, p. 267

  摘要：

  DOI：

文献信息

• Boronate ester cross-linked PVA hydrogels for the capture and H₂O₂-mediated release of active fluorophores
  作者：George T. Williams、Adam C. Sedgwick、Sajal Sen、Lauren Gwynne、Jordan E. Gardiner、James T. Brewster、Jennifer R. Hiscock、Tony D. James、A. Toby A. Jenkins、Jonathan L. Sessler

  DOI：10.1039/d0cc01904f

  日期：——

  A new set of H₂O₂-responsive PVA hydrogels were formed using the boronate fluorescent probe PF1 and the novel boronate fluorescent probe PT1 as the covalent crosslinkers.

  一组新的H₂O₂响应性PVA水凝胶是使用硼酸荧光探针PF1和新型硼酸荧光探针PT1作为共价交联剂形成的。
• Phenothiazine Derivatives: Mono-oxygenated Compounds
  作者：David F. Houston、E. B. Kester、Floyd. DeEds

  DOI：10.1021/ja01179a067

  日期：1949.11.19
• DE103301
  申请人：——

  公开号：——

  公开（公告）日：——
• Fate of the anthelmintic, phenothiazine, in man
  作者：S. C. Mitchell、P. Kestell、G. B. Steventon、R. H. Waring

  DOI：10.1080/00498250210143038

  日期：2002.1

  1. Radiolabelled [S-35]-phenothiazine has been administered orally to two healthy adult male volunteers (6 mg kg(-1) body weight). Faeces were the major route of excretion of radioactivity (68%), the remainder being eliminated via the urine (32%) with an estimated urinary half-life (biphasic) of 6-16 h. Over the 5 days of the study a complete recovery of radioactivity was achieved.2. From urinary data, it was shown that metabolism occurred via ring carbon oxidation to form phenothiazone and thionol and via ring sulphur oxidation to form phenothiazine sulphoxide. The majority of urinary material (92%) was present in the form of conjugates of phenothiazine and phenothiazone. Only unchanged phenothiazine was detected in the faeces. Phenothiazine sulphoxide was reduced to phenothiazine during incubation with faecal homogenates.
• Thionol and its Semiquinone Radical
  作者：S. Granick、L. Michaelis

  DOI：10.1021/ja01204a014

  日期：1947.12