1-bromo-7-methoxy-1,2,3,4-tetrahydronaphthalene | 305806-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-bromo-7-methoxy-1,2,3,4-tetrahydronaphthalene
• CAS: 305806-79-5
• 化学式: C₁₁H₁₃BrO
• 分子量: 241.128
• InChiKey: BUEHXKIZYPAADC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-bromo-7-methoxy-1,2,3,4-tetrahydronaphthalene 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以2.11 g的产率得到1-azido-7-methoxy-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Synthesis and evaluation of dimeric 1,2,3,4-Tetrahydro-naphthalenylamine and Indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity

  摘要：

  In a continuation of our studies into 4-Amino-3,4-dihydro-2H-naphthalen-1-ones as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimeric analogues. Of these derivatives, the most promising activity was seen with tertiary amine 58a, which exhibited potent mast cell-stabilising activity in vitro against a variety of stimuli and also in vivo against passive cutaneous anaphylaxis. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.09.020
• 作为产物：
  描述：

  阿戈美拉汀杂质醇(A) 在 三溴化磷 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以900 mg的产率得到1-bromo-7-methoxy-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  新型膦基-恶唑啉配体的开发及其在苄基卤化物不对称炔基化中的应用

  摘要：

  开发了一组新的立体化学多样化的膦基-恶唑啉配体，衍生自简单的L-氨基酸和 2-(二苯基膦基)苯甲酸。这些单阴离子三齿 N,N,P-配体以高产率和优异的对映选择性促进末端炔烃与多种苄基卤化物（包括苯并稠合环状 α-卤化物和 α-甲硅烷基苄基卤化物）的对映选择性自由基偶联。反应条件温和。具有多个不同的结构修饰位点，可以轻松访问各种手性 N、N、P 配体库，从而可以快速优化特定底物的配体结构。值得注意的是，苯并环分子中苄基卤键的对映选择性炔基化也是首次实现。

  DOI：

  10.1002/cjoc.202200074

文献信息

• [EN] WDR5 INHIBITORS AND MODULATORS<br/>[FR] MODULATEURS ET INHIBITEURS DE WDR5
  申请人：UNIV VANDERBILT

  公开号：WO2020247679A1

  公开（公告）日：2020-12-10

  Quinazolin-4(3H)-one, 2,3 -dihydroquinazolin-4(1H)-one, 3,4-dihydrobenzo[f][1,4]oxazepin- 5(2H)-one, and 3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

  喹唑啉-4(3H)-酮，2,3-二氢喹唑啉-4(1H)-酮，3,4-二氢苯并[f][1,4]噁唑啉-5(2H)-酮，以及3,4-二氢-1H-苯并[e][1,4]二氮杂环己二酮化合物及其衍生物抑制WDR5及相关蛋白质相互作用，这些化合物及其药物组合物可用于治疗受试者的疾病和症状，如癌细胞增殖。
• [EN] 9-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)-1,9-DIHYDROPURIN-6-ONE DERIVATIVES AS PDE7 INHIBITORS<br/>[FR] DERIVES DE 9-(1,2,3,4-TETRAHYDRONAPTHTHALENE-1-YLE)-1,9-DIHYDROPURINE-6-UN INHIBITEURS DE PDE7
  申请人：DARWIN DISCOVERY LTD

  公开号：WO2000068230A1

  公开（公告）日：2000-11-16

  Compounds of formula (i) wherein X-Y-Z represents NR4-C=N or N=C-NR4; R4, which can be attached to either X or Z, is a residue derived from 5,6,7,8- or 1,2,3,4-tetrahydro-naphthalene have therapeutic utility as inhibitors of PDE7.
• CN116947673
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis and evaluation of dimeric 1,2,3,4-Tetrahydro-naphthalenylamine and Indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity
  作者：James W. Barlow、John J. Walsh

  DOI：10.1016/j.ejmech.2009.09.020

  日期：2010.1

  In a continuation of our studies into 4-Amino-3,4-dihydro-2H-naphthalen-1-ones as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimeric analogues. Of these derivatives, the most promising activity was seen with tertiary amine 58a, which exhibited potent mast cell-stabilising activity in vitro against a variety of stimuli and also in vivo against passive cutaneous anaphylaxis. (C) 2009 Elsevier Masson SAS. All rights reserved.
• Development of Novel <scp>Phosphino‐Oxazoline</scp> Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides
  作者：Rui Guo、Jiale Sang、Haijing Xiao、Junxia Li、Guozhu Zhang

  DOI：10.1002/cjoc.202200074

  日期：2022.6

  ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)benzoic acid were developed. Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical coupling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclic α-halides and α-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions

  开发了一组新的立体化学多样化的膦基-恶唑啉配体，衍生自简单的L-氨基酸和 2-(二苯基膦基)苯甲酸。这些单阴离子三齿 N,N,P-配体以高产率和优异的对映选择性促进末端炔烃与多种苄基卤化物（包括苯并稠合环状 α-卤化物和 α-甲硅烷基苄基卤化物）的对映选择性自由基偶联。反应条件温和。具有多个不同的结构修饰位点，可以轻松访问各种手性 N、N、P 配体库，从而可以快速优化特定底物的配体结构。值得注意的是，苯并环分子中苄基卤键的对映选择性炔基化也是首次实现。