2,2,2-trifluoro-N-(4-methyl-1,3-thiazol-2-yl)acetamide | 59708-64-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2,2-trifluoro-N-(4-methyl-1,3-thiazol-2-yl)acetamide
• CAS: 59708-64-4
• 化学式: C₆H₅F₃N₂OS
• mdl: MFCD00460934
• 分子量: 210.18
• InChiKey: TVWWELUJVHZWDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-4-甲基噻唑 、 三氟乙酸酐 生成 2,2,2-trifluoro-N-(4-methyl-1,3-thiazol-2-yl)acetamide
  参考文献：
  名称：

  BIRKINSHAW, T. N.;HARKIN, S. A.;KAYE, P. T.;MEAKINS, G. D.;SMITH, A. K., J. CHEM. SOC. PERKIN TRANS., 1982, N 4, 939-943

  摘要：

  DOI：

文献信息

• Thiazolimine compound and oxazolimine compound
  申请人：Yamaguchi Hiroki

  公开号：US20070105908A1

  公开（公告）日：2007-05-10

  A compound represented by the formula (1): (wherein X represents sulfur or oxygen; R 1 and R 2 each represents a group represented by the formula —Y 3 -Z, etc.; Y 3 represents a single bond or (un)substituted alkylene; Y 1 and Y 2 each represents (un)substituted alkylene; Z represents hydrogen, an (un)saturated monocyclic heterocyclic group, etc.; M represents carboxy, etc.; Q represents o-phenylene, etc.; and A represents an (un)saturated monocyclic hydrocarbon group, etc.), a prodrug thereof, or a pharmaceutically acceptable salt of either. They are compounds having chymase inhibitory activity and useful as a therapeutic agent for hypertension, cardiac failure, etc.

  化合物的化学式为(1):(其中X代表硫或氧；R1和R2分别代表化学式为—Y3-Z等的基团；Y3代表单键或(未)取代的烷基；Y1和Y2分别代表(未)取代的烷基；Z代表氢、(未)饱和的单环杂环基团等；M代表羧基等；Q代表o-苯基等；A代表(未)饱和的单环烃基团等)、其前药或其药学上可接受的盐。它们是具有chymase抑制活性的化合物，并且可用作治疗高血压、心力衰竭等疾病的治疗剂。
• THIAZOLIMINE COMPOUND AND OXAZOLIMINE COMPOUND
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP1640369A1

  公开（公告）日：2006-03-29

  A compound represented by the formula (1): (wherein X represents sulfur or oxygen; R1 and R2 each represents a group represented by the formula -Y3-Z, etc.; Y3 represents a single bond or (un)substituted alkylene; Y1 and Y2 each represents (un)substituted alkylene; Z represents hydrogen, an (un)saturated monocyclic heterocyclic group, etc.; M represents carboxy, etc.; Q represents o-phenylene, etc.; and A represents an (un)saturated monocyclic hydrocarbon group, etc.), a prodrug thereof, or a pharmaceutically acceptable salt of either. They are compounds having chymase inhibitory activity and useful as a therapeutic agent for hypertension, cardiac failure, etc.

  式 (1) 所代表的化合物： (其中 X 代表硫或氧；R1 和 R2 各自代表由式-Y3-Z 等表示的基团；Y3 代表单键或(未)取代亚烷基；Y1 和 Y2 各自代表(未)取代亚烷基；Z 代表氢、(未)饱和单环杂环基团等；M 代表羧基等；Q 代表邻苯基等；A 代表(未)饱和单环烃基团等)。M代表羧基等；Q代表邻苯基等；A代表（未）饱和的单环烃基等）、其原药或二者的药学上可接受的盐。它们是具有糜蛋白酶抑制活性的化合物，可作为高血压、心力衰竭等的治疗药物。
• BIRKINSHAW, T. N.;HARKIN, S. A.;KAYE, P. T.;MEAKINS, G. D.;SMITH, A. K., J. CHEM. SOC. PERKIN TRANS., 1982, N 4, 939-943
  作者：BIRKINSHAW, T. N.、HARKIN, S. A.、KAYE, P. T.、MEAKINS, G. D.、SMITH, A. K.

  DOI：——

  日期：——