5-Octa-1,7-diynyl-2'-deoxyuridine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-Octa-1,7-diynyl-2'-deoxyuridine
• 英文别名: 1-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-octa-1,7-diynylpyrimidine-2,4-dione
• 化学式: C₁₇H₂₀N₂O₅
• 分子量: 332.4
• InChiKey: ZYWPRUZPBXIYJA-RBSFLKMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods and reagents for synthesising polynucleotide molecules
  申请人：Oxford Nanopore Technologies Limited

  公开号：US10927394B2

  公开（公告）日：2021-02-23

  The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.

  本发明涉及根据预定核苷酸序列合成多核苷酸分子的新方法。本发明还涉及合成后组装合成多核苷酸的方法，以及执行合成和/或组装方法的系统和试剂盒。
• New labelling strategies for the sensitive detection of analytes
  申请人：baseclick GmbH

  公开号：EP2256126B1

  公开（公告）日：2015-07-01
• MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS
  申请人：RANA THERAPEUTICS, INC.

  公开号：US20150247141A1

  公开（公告）日：2015-09-03

  The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided
• MULTIMERIC OLIGONUCLEOTIDES COMPOUNDS
  申请人：Uhlmann Eugen

  公开号：US20150299695A1

  公开（公告）日：2015-10-22

  The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
• METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING CLEAVABLE LINKERS
  申请人：RaNA Therapeutics, Inc.

  公开号：US20150315588A1

  公开（公告）日：2015-11-05

  The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided