7-[4-[[6-(cyclohexylamino)-7H-purin-2-yl]amino]phenoxy]-N-hydroxyheptanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-[4-[[6-(cyclohexylamino)-7H-purin-2-yl]amino]phenoxy]-N-hydroxyheptanamide
• 化学式: C₂₄H₃₃N₇O₃
• 分子量: 467.6
• InChiKey: LPHZEHLIRMVJSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• [EN] HETEROCYCLIC HYDROXAMIC ACIDS AS PROTEIN DEACETYLASE INHIBITORS AND DUAL PROTEIN DEACETYLASE-PROTEIN KINASE INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] ACIDES HYDROXAMIQUES HÉTÉROCYCLIQUES COMME INHIBITEURS DE PROTÉINE DÉSACÉTYLASE ET INHIBITEURS DOUBLES DE PROTÉINE KINASE-PROTÉINE DÉSACÉTYLASE, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV COLORADO REGENTS

  公开号：WO2015175813A1

  公开（公告）日：2015-11-19

  The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mpsl kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mpsl kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.

  本发明涉及一种新型的羟羧胺酸，它们是特异的组蛋白去乙酰化酶（HDAC）抑制剂和/或TTK/Mps1激酶抑制剂，包括其药用盐，用于调节HDAC和/或TTK/Mps1激酶活性，包括这些化合物的制药组合物，以及其制备方法。
• HETEROCYCLIC HYDROXAMIC ACIDS AS PROTEIN DEACETYLASE INHIBITORS AND DUAL PROTEIN DEACETYLASE-PROTEIN KINASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：The Regents of the University of Colorado, a body corporate

  公开号：EP3142652A1

  公开（公告）日：2017-03-22
• Heterocyclic Hydroxamic Acids as Protein Deacetylase Inhibitors and Dual Protein Deacetylase-Protein Kinase Inhibitors and Methods of Use Thereof
  申请人：The Regents of the University of Colorado, A Body Corporate

  公开号：US20170081343A1

  公开（公告）日：2017-03-23

  The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
• US9840520B2
  申请人：——

  公开号：US9840520B2

  公开（公告）日：2017-12-12
• USRE47690E1
  申请人：——

  公开号：USRE47690E1

  公开（公告）日：2019-11-05