5-Phenyl-1,3-benzothiazole-2-thiol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 5-Phenyl-1,3-benzothiazole-2-thiol
• 英文别名: 5-phenyl-3H-1,3-benzothiazole-2-thione
• 化学式: C₁₃H₉NS₂
• mdl: MFCD00458838
• 分子量: 243.353
• InChiKey: PNVQWHLXRYACFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-去甲基表鬼臼毒素 、 5-Phenyl-1,3-benzothiazole-2-thiol 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以55%的产率得到4β-S-(5-phenyl-benzothizole-2-)-4'-demethyl-4-desoxy-4'-demethylpipodophyllotoxin
  参考文献：
  名称：

  Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4′-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of 4′-demethylepipodophyllotoxin

  摘要：

  4 '-Demethylepipodophyllotoxin (DMEP) derivatives are broad-spectrum and potent antitumor leading compound. Because of their unacceptable toxicity, DMEP derivatives often failed in the development of new drug. Until now, there was no report on the millimolar-potency toxicity of DMEP derivatives by modifying the molecule structure of DMEP. For the first time, this work discovered leading compounds with millimolar-potency toxicity by modifying the molecule structure of DMEP. The IC50 value of 4 beta-S-(5-fluorobenzoxazole-2-)-4-deoxy-4 '-demethylepipodophyllotoxin (Compound 2) was around 323.4 2000.9 mu M on human healthy cells (i.e., HL-7702, H8, MRC-5 and HMEC), which was significantly reduced by 171-1999 times than podophyllotoxin (1.0-2.6 mu M) and 9-80 times than etoposide (21.5 75.4 mu M). Compared with the treatment of etoposide, DNA repair proteins HMGB1 and PARK7 were specifically activated and the expression of anti-apoptotic proteins were up-regulated in HL-7702 cells after the treatment of Compound 2. These indicated the toxicity of Compound 2 was synergistically reduced by DNA repair and anti-apoptosis pathway. (C) 2018 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2018.09.022

文献信息

• Process for the stabilization of mercaptobenzothiazole in a lubricating oil composition
  申请人：EXXON RESEARCH AND ENGINEERING COMPANY

  公开号：EP0207737A2

  公开（公告）日：1987-01-07

  There is disclosed a process for the solubilization of a mercaptobenzothiazole amine salt with a solvent such as dihexyl phthalate which solubilized salt is in turn suitable for dissolution into a lubricating oil composition, such as an automatic transmission fluid, even at room temperature.

  本发明公开了一种用邻苯二甲酸二己酯等溶剂增溶巯基苯并噻唑胺盐的工艺，增溶后的盐即使在室温下也适合溶解到自动变速箱油等润滑油组合物中。
• Rubber composition for tire tread and pneumatic tire using the rubber composition
  申请人：BRIDGESTONE CORPORATION

  公开号：EP0818500A1

  公开（公告）日：1998-01-14

  The present invention provides a rubber composition for a tire tread which comprises 100 parts by weight of a rubber component comprising 50 parts by weight or more of SBR and the remaining amount of a synthetic rubber and/or natural rubber, 25 parts by weight or more of a softener, and 0.5 to 5.0 parts by weight of a vulcanization accelerator, such as bis(4-methylbenzothiazolyl-2)-disulfide, bis(5-methylbenzothiazolyl-2)-disulfide, mercapto-4-methylbenzothiazole, and mercapto-5-methylbenzothiazole, and a pneumatic tire produced by using this rubber composition. A tire having excellent controllability and ride quality throughout tire life can be provided.

  本发明提供了一种用于轮胎胎面的橡胶组合物，该组合物包括 100 份（按重量计）的橡胶组分，其中 50 份（按重量计）或更多的丁苯橡胶和剩余量的合成橡胶和/或天然橡胶，25 份（按重量计）或更多的软化剂，以及 0.5 至 5.0 重量份的硫化促进剂，如双(4-甲基苯并噻唑-2)-二硫化物、双(5-甲基苯并噻唑-2)-二硫化物、巯基-4-甲基苯并噻唑和巯基-5-甲基苯并噻唑，以及使用这种橡胶组合物生产的充气轮胎。这种轮胎在整个轮胎寿命期间都具有优异的可控性和行驶质量。
• Agricultural or industrial tire with reinforced rubber composition
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1559587A2

  公开（公告）日：2005-08-03

  The present invention is directed a pneumatic agricultural or industrial tire (20) comprising a casing (21) and a rubber tread (32A, 32B, 34) disposed radially outwardly of the casing (21), the tread having an inner tread (34) and a plurality of tread lugs (50) projecting radially from the inner tread (34), said casing (21) having at least one component (22, 26, 28), said component comprising textile cord and a rubber composition in contact with the textile cord, the rubber composition comprising    100 parts by weight of at least one diene based elastomer, including from 75 to 15 parts by weight of polybutadiene and 25 to 85 parts by weight of at least one additional diene based elastomer selected from the group consisting of styrene-butadiene rubber, synthetic polyisoprene and natural polyisoprene;    0.1 to 8 parts by weight of at least one accelerator selected from benzothiazoles and dithiophosphates and exclusive of sulfenamides;    1 to 15 parts by weight of at least one resin selected from phenolformaldehyde resins, aliphatic cyclic hydrocarbon resins, and aromatic hydrocarbon resin;    10 to 150 parts by weight of a filler selected from the group consisting of carbon black, silica, and starch/plasticizer composite filler; and    0.3 to 3 parts by weight of sulfur;    wherein each lug has a width in a range of from 2 cm to 10 cm and length in a range of from 2 cm to 60 cm, and a height in a range of from 2 cm to 10 cm, and wherein the tread has a net-to-gross ratio in a range of from 15 to 40 percent as measured around the entire 360° circumference of a normally inflated and normally loaded tire contacting a flat hard surface.

  本发明涉及一种充气农业或工业轮胎（20），包括胎体（21）和从胎体（21）径向向外设置的橡胶胎面（32A、32B、34），胎面具有内胎面（34）和从内胎面（34）径向伸出的多个胎耳（50），所述胎体（21）具有至少一个部件（22、26、28），所述部件包括纺织帘线和与纺织帘线接触的橡胶组合物，所述橡胶组合物包括 100 份（按重量计）至少一种二烯基弹性体，包括 75 至 15 份（按重量计）聚丁二烯和 25 至 85 份（按重量计）至少另外一种二烯基弹性体，该弹性体选自由丁苯橡胶、合成聚异戊二烯和天然聚异戊二烯组成的组； 0.1 至 8 份（按重量计）至少一种促进剂，该促进剂选自苯并噻唑和二硫代磷酸 酯，但不包括亚氨基磺酸盐； 1 至 15 份（按重量计）至少一种树脂，选自苯酚甲醛树脂、脂肪族环状烃树脂和芳香族烃树脂； 10 至 150 份（按重量计）选自碳黑、二氧化硅和淀粉/增塑剂复合填料组的填料；以及 0.3 至 3 重量份的硫； 其中每个胎耳的宽度范围为 2 厘米至 10 厘米，长度范围为 2 厘米至 60 厘米，高度范围为 2 厘米至 10 厘米，并且胎面的净毛比范围为 15%至 40%，该范围是在正常充气和正常装载的轮胎接触平硬表面的整个 360° 圆周上测量的。
• Rubber composition for cap tread and studless tire
  申请人：Sumitomo Rubber Industries, Ltd.

  公开号：EP2325242A1

  公开（公告）日：2011-05-25

  The present invention aims to provide a rubber composition that improves heat resistance and particularly inhibits the changes in properties such as hardness of the vulcanized rubber composition (rubber hardening degradation) due to long-term use without an increased amount of an age resistor, thereby extending the life-span without deterioration of performance on ice, and reduces vulcanization time while maintaining good scorch resistance, and increases cross-linking efficiency; and a studless tire having a cap tread produced from the composition. The rubber composition for a cap tread of the invention comprises: a rubber component containing an isoprene-based rubber; silica; a compound represented by formula (I) and/or (II); and a thiuram vulcanization accelerator, wherein R1 and R2 may be the same or different, and each represent a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group, provided that the case where R1 and R2 are simultaneously hydrogen atoms is excluded.

  本发明旨在提供一种橡胶组合物，该组合物可提高耐热性，尤其可抑制硫化橡胶组合物因长期使用而导致的硬度等性能变化（橡胶硬化降解），且无需增加抗老化剂的用量，从而可延长使用寿命而不会降低冰上性能，并可缩短硫化时间，同时保持良好的耐焦烧性，还可提高交联效率；以及一种无钉轮胎，该轮胎具有由该组合物生产的盖胎面。本发明的盖胎面橡胶组合物包括：含有异戊二烯基橡胶的橡胶组分；白炭黑；由式（I）和/或（II）代表的化合物；以及秋兰姆硫化促进剂、 其中 R1 和 R2 可以相同或不同，各自代表氢原子、烷基、芳基或芳烷基，但不包括 R1 和 R2 同时为氢原子的情况。
• COMPOSITION, COMPOSITE FILM AND MEMBRANE ELECTRODE ASSEMBLY
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：EP3611224A1

  公开（公告）日：2020-02-19

  The present invention provides: a composition including 100.0 parts by mass of a perfluorocarbon polymer having an ion-exchange group (A); and 0.1 to 200.0 parts by mass of a basic polymer (B), and a composition including a polyimide having a structure represented by formula (1): wherein Y represents a tetravalent organic group.

  本发明提供了 一种组合物，包括按质量份数计 100.0 份具有离子交换基团的全氟碳聚合物 (A)；和按质量份数计 0.1 至 200.0 份碱性聚合物 (B)，以及 一种组合物，包括具有式 (1) 所示结构的聚酰亚胺： 其中 Y 代表四价有机基团。