N-(1-oxo-2,2,6,6-tetramethylpiperidin-4-yl)-pivalamide | 22977-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-oxo-2,2,6,6-tetramethylpiperidin-4-yl)-pivalamide
• CAS: 22977-60-2
• 化学式: C₁₄H₂₇N₂O₂
• 分子量: 255.381
• InChiKey: KBXBZNWQMJCXEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  33.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-oxo-2,2,6,6-tetramethylpiperidin-4-yl)-pivalamide 、 3-氰基苄基溴 在 copper(II) bis(trifluoromethanesulfonate) 、 铜 4,4'-二叔丁基-2,2'-二吡啶 作用下， 以 苯 为溶剂， 以0.420 g的产率得到2,2-dimethyl-N-(1-(3-cyanobenzyloxy)-2,2,6,6-tetramethyl-4-piperidinyl)propionamide
  参考文献：
  名称：

  Heterobivalent Library Expansion by “Living Radical” Processes:  Thiocarbonyl Addition/Elimination, and Nitroxide-Based Reactions with Fluorous Deconvolution

  摘要：

  Degenerate radical addition fragmentation and nitroxide fragmentation reactions are applied to the expansion of heterobivalent libraries without contamination from homobivalent species. Deconvolution by means of a fluorous tagging process is described.

  DOI：

  10.1021/ja0756321
• 作为产物：
  描述：

  三甲基乙酰氯 、 4-氨基-TEMPO 在 4-二甲氨基吡啶 吡啶 作用下， 反应 3.0h， 生成 N-(1-oxo-2,2,6,6-tetramethylpiperidin-4-yl)-pivalamide
  参考文献：
  名称：

  Heterobivalent Library Expansion by “Living Radical” Processes:  Thiocarbonyl Addition/Elimination, and Nitroxide-Based Reactions with Fluorous Deconvolution

  摘要：

  Degenerate radical addition fragmentation and nitroxide fragmentation reactions are applied to the expansion of heterobivalent libraries without contamination from homobivalent species. Deconvolution by means of a fluorous tagging process is described.

  DOI：

  10.1021/ja0756321

文献信息

• Heterobivalent Library Expansion by “Living Radical” Processes:  Thiocarbonyl Addition/Elimination, and Nitroxide-Based Reactions with Fluorous Deconvolution
  作者：David Crich、Daniel Grant、Albert A. Bowers

  DOI：10.1021/ja0756321

  日期：2007.10.1

  Degenerate radical addition fragmentation and nitroxide fragmentation reactions are applied to the expansion of heterobivalent libraries without contamination from homobivalent species. Deconvolution by means of a fluorous tagging process is described.