4-diethylamino-2-methylquinazoline | 57942-17-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-diethylamino-2-methylquinazoline
• 英文别名: 4-Diaethylamino-2-methyl-chinazolin；diethyl-(2-methyl-quinazolin-4-yl)-amine；N,N-diethyl-2-methyl-4-quinazolinamine；N,N-diethyl-2-methylquinazolin-4-amine
• CAS: 57942-17-3
• 化学式: C₁₃H₁₇N₃
• mdl: MFCD02034993
• 分子量: 215.298
• InChiKey: MQUFDVBSDSPMEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-叠氮基-2-甲基喹啉 在 sodium methylate 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 12.5h， 生成 4-diethylamino-2-methylquinazoline
  参考文献：
  名称：

  Thermal Ring Contraction of 3H-1,4-Benzodiazepines into Quinazolines

  摘要：

  DOI：

  10.3987/com-99-8639

文献信息

• YAXONTOV L. N.; ZHIXAREVA G. P.; PRONINA E. V.; PERSHIN G. N.; LIBERMAN S+, XIM.-FARMATSEVT. ZH. <KNFZ-AN>, 1975, 9, HO 11, 12-18
  作者：YAXONTOV L. N.、 ZHIXAREVA G. P.、 PRONINA E. V.、 PERSHIN G. N.、 LIBERMAN S+

  DOI：——

  日期：——
• [EN] COMPOUNDS AND METHODS FOR PREVENTING, TREATING, OR AMELIORATING AIRWAY DISEASE<br/>[FR] COMPOSÉS ET MÉTHODES POUR PRÉVENIR, TRAITER OU AMÉLIORER UNE MALADIE DES VOIES RESPIRATOIRES
  申请人：[en]THOMAS JEFFERSON UNIVERSITY

  公开号：WO2022173743A1

  公开（公告）日：2022-08-18

  The β2-adrenergic receptor (β2AR) is a primary target in the treatment of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Since β-agonist treatment of airway disease can have severe side effects, compounds that attenuate the side effects of β-agonists have been identified via their ability to inhibit β2AR interaction with β-arrestins. These compounds are specific for the β2AR and effectively protect against the desensitization observed with β-agonist treatment in model cells and airway tissue. The present disclosure provides compounds and methods for treating airway disease, such as but not limited to COPD and/or asthma.
• Thermal Ring Contraction of 3H-1,4-Benzodiazepines into Quinazolines
  作者：Haruki Sashida、Mamoru Kaname、Takashi Tsuchiya

  DOI：10.3987/com-99-8639

  日期：——