8-氨基-1H-苯并吡喃并[3,2-b]吡啶-6(7H)-酮 | 54629-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 8-氨基-1H-苯并吡喃并[3,2-b]吡啶-6(7H)-酮
• 英文名称: 7-amino-5H-[1]benzopyrano[2,3-b]pyridin-5-one
• 英文别名: 7-amino-chromeno[2,3-b]pyridin-5-one；7-amino-5H-chromeno[2,3-b]pyridin-5-one；7-aminochromeno[2,3-b]pyridin-5-one
• CAS: 54629-26-4
• 化学式: C₁₂H₈N₂O₂
• 分子量: 212.208
• InChiKey: FQCQTEUUNFORPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  8-氨基-1H-苯并吡喃并[3,2-b]吡啶-6(7H)-酮 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以93%的产率得到6-Amino-1,2,3,4-tetrahydro-9-oxa-1-aza-anthracen-10-one
  参考文献：
  名称：

  Pasutto, Franco M.; Abuzar, Syed; Satyamurthy, Srinivasamurthy, Heterocycles, 1985, vol. 23, # 9, p. 2293 - 2297

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苯氧基烟酸 在 palladium on activated charcoal PPA 、 硫酸 、 氢气 、 potassium nitrate 作用下， 以 乙醇 为溶剂， -5.0~120.0 ℃ 、413.69 kPa 条件下， 反应 16.0h， 生成 8-氨基-1H-苯并吡喃并[3,2-b]吡啶-6(7H)-酮
  参考文献：
  名称：

  Benzopyranopyridine derivatives. 1. Aminoalkyl derivatives of the azaxanthenes as bronchodilating agents

  摘要：

  The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the profile of an orally effective potent bronchodilating agent as well as a moderate antihistamine. Biological properties of this compound were compared to a number of antihistamines as well as known bronchodilating agents. Structure-activity relationships are also discussed.

  DOI：

  10.1021/jm00235a001

文献信息

• Synthesis of Pyridopyranoquinolines by the Skraup Reaction of Amino-5H -benzopyrano[2,3-b]pyridin-5-ones
  作者：Hidetoshi Fujiwara、Kouki Kitagawa

  DOI：10.3987/com-99-8753

  日期：——

  7-, 8- and 9-Amino-5H-[1]benzopyrano[2,3-b]-pyridin-5-ones were synthesized. Skraup reaction of 6-Amino-, 7-amino-, 8-amino- and 9-Amino-5H-[1]benzopyrano[2,3-b]pyridin-5-ones in the presence of glycerol, fuming sulfuric acid, nitrobenzene, iron(II) sulfate and boric acid gave 12H-pyrido[3',2':5,6]pyrano[2,3-h]-quinolin-12-one, 12H-pyrido[3',2':5,6]pyrano[3,2-f]-quinolin-12-one, 7H-pyrido[3',2':5,6]pyrano[2,3-f]quinolin-7-one and 7H-pyrido[3',2':5,6]pyrano[3,2-h]quinolin-7-one, respectively.
• PASUTTO, F. M.;ABUZAR, SYED;SATYAMURTHY, STRINIVASAMURTHY, HETEROCYCLES, 1985, 23, N 9, 2293-2297
  作者：PASUTTO, F. M.、ABUZAR, SYED、SATYAMURTHY, STRINIVASAMURTHY

  DOI：——

  日期：——
• VILLANI F. J.; MANN T. A.; WEFER E. A.; HANNON J.; LARCA L. L.; LANDON M.+, J. MED. CHEM. <JMCM-AR>, 1975, 18, NO 1, 1-8
  作者：VILLANI F. J.、 MANN T. A.、 WEFER E. A.、 HANNON J.、 LARCA L. L.、 LANDON M.+

  DOI：——

  日期：——
• Benzopyranopyridine derivatives. 1. Aminoalkyl derivatives of the azaxanthenes as bronchodilating agents
  作者：Frank J. Villani、Thomas A. Mann、Elizabeth A. Wefer、Janet Hannon、Louis L. Larca、Mildred J. Landon、William Spivak、Dhiru Vashi、Salvatore Tozzi

  DOI：10.1021/jm00235a001

  日期：1975.1

  The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the profile of an orally effective potent bronchodilating agent as well as a moderate antihistamine. Biological properties of this compound were compared to a number of antihistamines as well as known bronchodilating agents. Structure-activity relationships are also discussed.
• Pasutto, Franco M.; Abuzar, Syed; Satyamurthy, Srinivasamurthy, Heterocycles, 1985, vol. 23, # 9, p. 2293 - 2297
  作者：Pasutto, Franco M.、Abuzar, Syed、Satyamurthy, Srinivasamurthy

  DOI：——

  日期：——