6-acetyl-2,3-dihydroperimidine | 1198394-91-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-acetyl-2,3-dihydroperimidine
• 英文别名: 1-(2,3-dihydro-1H-perimidin-6-yl)ethanone
• CAS: 1198394-91-0
• 化学式: C₁₃H₁₂N₂O
• 分子量: 212.251
• InChiKey: ALCUABGCMLQBKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-acetyl-2,3-dihydroperimidine 在 PPA 、 溶剂黄146 作用下， 反应 1.0h， 以63%的产率得到4(9)-acetylperimidine
  参考文献：
  名称：

  Synthesis of 2,3-dihydroperimidine ketones

  摘要：

  Ketones derived from unsubstituted 2,3-dihydroperimidine were obtained by the selective reduction of the corresponding acylperimidines. The direct acylation of 2,3-dihydroperimidine in PPA is accompanied by dehydrogenation and leads to 4(9)-acylperimidines. The spectral characteristics of these products were discussed.

  DOI：

  10.1007/s10593-009-0325-4
• 作为产物：
  描述：

  6(7)-acetylperimidine 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 反应 1.0h， 以78%的产率得到6-acetyl-2,3-dihydroperimidine
  参考文献：
  名称：

  Synthesis of 2,3-dihydroperimidine ketones

  摘要：

  Ketones derived from unsubstituted 2,3-dihydroperimidine were obtained by the selective reduction of the corresponding acylperimidines. The direct acylation of 2,3-dihydroperimidine in PPA is accompanied by dehydrogenation and leads to 4(9)-acylperimidines. The spectral characteristics of these products were discussed.

  DOI：

  10.1007/s10593-009-0325-4

文献信息

• Synthesis of 2,3-dihydroperimidine ketones
  作者：I. V. Borovlev、O. P. Demidov

  DOI：10.1007/s10593-009-0325-4

  日期：2009.6

  Ketones derived from unsubstituted 2,3-dihydroperimidine were obtained by the selective reduction of the corresponding acylperimidines. The direct acylation of 2,3-dihydroperimidine in PPA is accompanied by dehydrogenation and leads to 4(9)-acylperimidines. The spectral characteristics of these products were discussed.