4-Chlorthian | 32358-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: 4-Chlorthian
• 英文别名: 4-Chlor-thiacyclohexan；4-chloro-tetrahydro-thiopyran；4-Chlor-tetrahydro-thiopyran；4-chlorotetrahydro-2H-thiopyran；4-chlorothiane
• CAS: 32358-87-5
• 化学式: C₅H₉ClS
• 分子量: 136.645
• InChiKey: MDXKZPMYXHDPMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  四氢噻喃-4-醇 在 吡啶 、 氯化亚砜 、 氯仿 作用下， 生成 4-Chlorthian
  参考文献：
  名称：

  Adlerova; Protiva, Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 1268,1270

  摘要：

  DOI：

文献信息

• Method for producing organic compounds by substituting halogen atoms
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1486479A1

  公开（公告）日：2004-12-15

  The invention pertains to a method in which a halogen atom of an organic compound is replaced with a group derived from a nucleophilic agent, at high yield and high efficiency, by the following method which includes a step of reacting the nucleophilic agent with an organic material having a halogen atom bonded to a carbon atom having four σ bonds, more specifically: a method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four σ bonds so as to replace the halogen atom in the organic starting material with Q:         MQa     (2) (wherein M represents an alkali metal atom, an alkali earth metal atom, or a rare earth metal atom; Q represents a moiety of an inorganic acid or an active hydrogen compound derived by eliminating a proton, wherein Q is a halogen atom different from the halogen atom in the organic starting material having the halogen atom bonded to the carbon atom having the four σ bonds; and a represents an integer of 1 to 3) in the presence of a compound represented by general formula (1) (wherein Z- represents an anion derived by eliminating a proton from an inorganic acid or an active hydrogen compound; R2 is the same or different; R2 each independently represent a C1-C10 hydrocarbon group or two R2 on the same nitrogen atom may be bonded with each other to form a ring with the nitrogen atom).

  这项发明涉及一种方法，其中有机化合物中的卤素原子被来自亲核试剂的基团取代，且产率高效率高，通过以下方法实现，包括以下步骤：将亲核试剂与具有与碳原子形成四个σ键的卤素原子相结合的有机材料反应的步骤，更具体地说：一种用于生产具有Q的有机化合物的方法，包括以下步骤：将由通式（2）表示的化合物与至少一个卤素原子与碳原子形成四个σ键的有机起始材料反应，以将有机起始材料中的卤素原子替换为Q：         MQa     (2) （其中M代表碱金属原子、碱土金属原子或稀土金属原子；Q代表由消除质子衍生的无机酸或活性氢化合物的基团，其中Q是不同于有机起始材料中卤素原子的卤素原子，该卤素原子与具有四个σ键的碳原子相结合；a表示1到3的整数），在通式（1）表示的化合物的存在下 （其中Z-代表由无机酸或活性氢化合物中消除质子衍生的阴离子；R2相同或不同；R2各自独立地表示C1-C10烃基，或者两个R2在同一氮原子上可能与彼此结合形成与氮原子的环）。
• [EN] SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME<br/>[FR] MODULATEURS CYCLIQUES SUBSTITUÉS DE PROTÉINE PHOSPHATASE 2A (PP2A) ET LEURS PROCÉDÉS D'UTILISATION
  申请人：RAPPTA THERAPEUTICS OY

  公开号：WO2022167867A1

  公开（公告）日：2022-08-11

  The present disclosure relates in part to chemical modulators of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, autoimmune disease, solid organ transplant rejection, graft vs host disease, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease, abdominal aortic aneurysm, chronic liver disease, heart failure, neurodegenerative disease, and cardiac hypertrophy.

  本公开涉及部分蛋白磷酸酶2A（PP2A）的化学调节剂。本公开的化合物可用于治疗、预防和/或改善癌症、糖尿病、自身免疫性疾病、固体器官移植排斥、移植物抗宿主病、慢性阻塞性肺疾病（COPD）、非酒精性脂肪性肝病、腹主动脉瘤、慢性肝病、心力衰竭、神经退行性疾病和心肌肥厚。
• Method for producing organic compound by substituting halogen atoms
  申请人：Mitsui Chemicals, Inc.

  公开号：US20040256743A1

  公开（公告）日：2004-12-23

  A method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four &sgr; bonds so as to replace the halogen atom in the organic starting material with Q: MQ a (2) wherein M, Q and a are defined in the presence of a compound represented by general formula (1) 1 wherein Z − and Rs are also defined.

  一种生产具有 Q 的有机化合物的方法，该方法包括以下步骤：将通式（2）代表的化合物与有机起始材料反应，该有机起始材料具有至少一个与具有四个&sgr;键的碳原子成键的卤原子，从而用 Q 取代有机起始材料中的卤原子： MQ a (2) 其中 M、Q 和 a 是在通式（1）所代表的化合物存在时定义的 1 其中 Z - 和 Rs 也已定义。
• Adlerova; Protiva, Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 1268,1270
  作者：Adlerova、Protiva

  DOI：——

  日期：——

表征谱图