Dihexanoylphosphatidylcholin

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: Dihexanoylphosphatidylcholin
• 英文别名: 2-[2,3-di(hexanoyloxy)propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C₂₀H₄₁NO₈P
• 分子量: 454.521
• InChiKey: DVZARZBAWHITHR-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Therapies for treating and preventing chronic rhinosinusitis
  申请人：Avanti Polar Lipids, LLC

  公开号：US11413297B2

  公开（公告）日：2022-08-16

  The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.

  本发明提供了破坏已形成的细菌生物膜或防止形成细菌生物膜的组合物和方法。本发明还提供了治疗和预防慢性鼻炎的方法和组合物。此类组合物和方法利用一种或多种抗生素化合物与本文所述的至少一种磷脂化合物相结合。
• PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS
  申请人：GRI Bio, Inc.

  公开号：EP3229811B1

  公开（公告）日：2021-02-24
• NOVEL THERAPIES FOR TREATING AND PREVENTING CHRONIC RHINOSINUSITIS
  申请人：The Scripps Research Institute

  公开号：EP3684180A1

  公开（公告）日：2020-07-29
• [EN] NOVEL THERAPIES FOR TREATING AND PREVENTING CHRONIC RHINOSINUSITIS<br/>[FR] NOUVELLES THÉRAPIES DESTINÉES À TRAITER ET PRÉVENIR UNE RHINO-SINUSITE CHRONIQUE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2019060761A1

  公开（公告）日：2019-03-28

  The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.
• [EN] UNIDIRECTIONAL PRESENTATION OF MEMBRANE PROTEINS IN NANOPARTICLE-SUPPORTED LIPOSOMES<br/>[FR] PRÉSENTATION UNIDIRECTIONNELLE DE PROTÉINES MEMBRANAIRES DANS DES LIPOSOMES SUPPORTÉS PAR DES NANOPARTICULES
  申请人：HARVARD COLLEGE

  公开号：WO2020139963A1

  公开（公告）日：2020-07-02

  Presentation of membrane proteins to host immune systems has been a challenging problem due to complexity arising from the poor in vivo stability of the membrane-mimetic media often used for solubilizing the membrane proteins. The Inventors report the use of functionalized, biocompatible nanoparticles as substrates to guide the formation of proteoliposomes that can present many copies of membrane proteins in a unidirectional manner. The approach was demonstrated to present the membrane-proximal region of the HIV-1 envelope glycoprotein. These nanoparticle-supported liposomes are broadly applicable as membrane antigen vehicles for inducing host immune responses. In some instances, the technology supports generation of antibodies that do not generate an immunogenic response in comparison to conventional protein presentation (i.e., liposome).