9-Cyclohexyl-2-amino-6-mercapto-9H-purin | 24398-00-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-Cyclohexyl-2-amino-6-mercapto-9H-purin
• 英文别名: 2-amino-9-cyclohexyl-1,9-dihydro-purine-6-thione；2-azanyl-9-cyclohexyl-3~{H}-purine-6-thione；2-amino-9-cyclohexyl-3H-purine-6-thione
• CAS: 24398-00-3
• 化学式: C₁₁H₁₅N₅S
• 分子量: 249.34
• InChiKey: PKVXHQDYPCXSAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  70.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL MODULATORS OF NRF2 AND USES THEREOF
  申请人：Batist Gerald

  公开号：US20130137694A1

  公开（公告）日：2013-05-30

  There is provided modulators of Nrf2 protein which comprises a compound which binds at least one of the BTB domain, IVR domain and Kelch domain of Keap1 protein, activating or inhibiting Nrf2. There is also provided pharmaceutical compositions containing the modulators, as well as uses and method of use of the modulators for the treatment of conditions.
• US9139592B2
  申请人：——

  公开号：US9139592B2

  公开（公告）日：2015-09-22
• [EN] NOVEL MODULATORS OF NRF2 AND USES THEREOF<br/>[FR] NOUVEAUX MODULATEURS DE LA NRF2 ET LEURS UTILISATIONS
  申请人：TRT PHARMA INC

  公开号：WO2011156889A1

  公开（公告）日：2011-12-22

  There is provided modulators of Nrf2 protein which comprises a compound which binds at least one of the BTB domain, IVR domain and Kelch domain of Keap1 protein, activating or inhibiting Nrf2. There is also provided pharmaceutical compositions containing the modulators, as well as uses and method of use of the modulators for the treatment of conditions.