2-(3-methyl-1-(pyrimidin-2-yl)-1H-indol-2-yl)isoindoline-1,3-dione | 1607824-35-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(3-methyl-1-(pyrimidin-2-yl)-1H-indol-2-yl)isoindoline-1,3-dione
• 英文别名: 2-(3-Methyl-1-pyrimidin-2-ylindol-2-yl)isoindole-1,3-dione；2-(3-methyl-1-pyrimidin-2-ylindol-2-yl)isoindole-1,3-dione
• CAS: 1607824-35-0
• 化学式: C₂₁H₁₄N₄O₂
• 分子量: 354.368
• InChiKey: MQRWCEZWBJHLSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  68.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻苯二甲酸亚胺 、 3-methyl-1-(pyrimidin-2-yl)-1H-indole 在 氧气 、 copper (I) acetate 作用下， 以 邻二氯苯 、 甲苯 为溶剂， 150.0 ℃ 、101.33 kPa 条件下， 以46%的产率得到2-(3-methyl-1-(pyrimidin-2-yl)-1H-indol-2-yl)isoindoline-1,3-dione
  参考文献：
  名称：

  Cu-Catalyzed Direct Amidation of Aromatic C–H Bonds: An Access to Arylamines

  摘要：

  A Cu-catalyzed aromatic C-H amidation with phthalimide under oxygen as a terminal oxidant without using additional additives has been achieved. This reaction has the broad substrate scope and shows moderate to good yields in most cases. This method is complementary to the previously reported metal-catalyzed C-H amination systems.

  DOI：

  10.1021/jo5003592

文献信息

• Cu-Catalyzed Direct Amidation of Aromatic C–H Bonds: An Access to Arylamines
  作者：Hui Xu、Xixue Qiao、Shiping Yang、Zengming Shen

  DOI：10.1021/jo5003592

  日期：2014.5.16

  A Cu-catalyzed aromatic C-H amidation with phthalimide under oxygen as a terminal oxidant without using additional additives has been achieved. This reaction has the broad substrate scope and shows moderate to good yields in most cases. This method is complementary to the previously reported metal-catalyzed C-H amination systems.