8-Chloro-5-methoxy-3,4-dihydro-naphthalene-2-carboxylic acid | 63214-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-Chloro-5-methoxy-3,4-dihydro-naphthalene-2-carboxylic acid
• 英文别名: 8-Chloro-5-methoxy-3,4-dihydronaphthalene-2-carboxylic acid
• CAS: 63214-82-4
• 化学式: C₁₂H₁₁ClO₃
• 分子量: 238.671
• InChiKey: WBXWDFVKQGXQPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-Chloro-5-methoxy-3,4-dihydro-naphthalene-2-carboxylic acid 、 环己胺 生成 (8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-cyclohexyl-amine
  参考文献：
  名称：

  Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes

  摘要：

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.

  DOI：

  10.1021/jm00201a004
• 作为产物：
  描述：

  8-Chloro-5-methoxy-3,4-dihydro-naphthalene-2-carboxylic acid ethyl ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 8-Chloro-5-methoxy-3,4-dihydro-naphthalene-2-carboxylic acid
  参考文献：
  名称：

  Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes

  摘要：

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.

  DOI：

  10.1021/jm00201a004

文献信息

• WELCH W. M.; PLATTNER J. J.; STRATTEN W. P.; HARBERT C. A., J. MED. CHEM., 1978, 21, NO 3, 257-263
  作者：WELCH W. M.、 PLATTNER J. J.、 STRATTEN W. P.、 HARBERT C. A.

  DOI：——

  日期：——
• US4022791A
  申请人：——

  公开号：US4022791A

  公开（公告）日：1977-05-10
• Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes
  作者：Willard M. Welch、J. J. Plattner、Wilford P. Stratten、C. A. Harbert

  DOI：10.1021/jm00201a004

  日期：1978.3

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.