(8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-cyclopropylmethyl-amine | 63215-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-cyclopropylmethyl-amine
• 英文别名: N-[(8-chloro-5-methoxy-3,4-dihydronaphthalen-2-yl)methyl]-1-cyclopropylmethanamine
• CAS: 63215-10-1
• 化学式: C₁₆H₂₀ClNO
• 分子量: 277.794
• InChiKey: NHJQLGDQQIIXKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  8-Chloro-5-methoxy-3,4-dihydro-naphthalene-2-carboxylic acid ethyl ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 (8-Chloro-5-methoxy-3,4-dihydro-naphthalen-2-ylmethyl)-cyclopropylmethyl-amine
  参考文献：
  名称：

  Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes

  摘要：

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.

  DOI：

  10.1021/jm00201a004

文献信息

• WELCH W. M.; PLATTNER J. J.; STRATTEN W. P.; HARBERT C. A., J. MED. CHEM., 1978, 21, NO 3, 257-263
  作者：WELCH W. M.、 PLATTNER J. J.、 STRATTEN W. P.、 HARBERT C. A.

  DOI：——

  日期：——
• Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes
  作者：Willard M. Welch、J. J. Plattner、Wilford P. Stratten、C. A. Harbert

  DOI：10.1021/jm00201a004

  日期：1978.3

  Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.