16-mercapto hexadecyl trimethylammonium bromide | 1362855-78-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 16-mercapto hexadecyl trimethylammonium bromide
• 英文别名: (16-Mercaptohexadecyl)trimethylammonium bromide；trimethyl(16-sulfanylhexadecyl)azanium;bromide
• CAS: 1362855-78-4
• 化学式: Br*C₁₉H₄₂NS
• 分子量: 396.519
• InChiKey: YOWQTEIQEJTXFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,16-二溴十六烷 在 sodium methylate 、 乙酰氯 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 16-mercapto hexadecyl trimethylammonium bromide
  参考文献：
  名称：

  Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy

  摘要：

  具有阳离子表面修饰的金纳米颗粒可以通过增强细胞摄取来增强X射线放疗的效果。

  DOI：

  10.1039/c5tb00766f

文献信息

• Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy
  作者：Chaoming Wang、An Sun、Yong Qiao、Peipei Zhang、Liyuan Ma、Ming Su

  DOI：10.1039/c5tb00766f

  日期：——

  Gold nanoparticles with cationic surface modification can enhance X-ray radiation therapy by enhancing cellular uptake.

  具有阳离子表面修饰的金纳米颗粒可以通过增强细胞摄取来增强X射线放疗的效果。
• Quantitative Replacement of Cetyl Trimethylammonium Bromide by Cationic Thiol Ligands on the Surface of Gold Nanorods and Their Extremely Large Uptake by Cancer Cells
  作者：Leonid Vigderman、Pramit Manna、Eugene R. Zubarev

  DOI：10.1002/anie.201107304

  日期：2012.1.16

  Stable and biocompatible: The chemical composition of synthesized cationic thiolate‐monolayer‐protected gold nanorods was precisely determined. In vitro cell culture experiments showed no cytotoxicity of these nanorods, and the number of nanorods that were taken up by each cancer cell exceeded two million particles (see picture).

  稳定且具有生物相容性：精确确定了合成的阳离子硫醇盐单层保护的金纳米棒的化学组成。体外细胞培养实验显示这些纳米棒没有细胞毒性，每个癌细胞吸收的纳米棒数量超过200万个颗粒（见图）。
• METHIONINE METABOLITES PREDICT AGGRESSIVE CANCER PROGRESSION
  申请人：Cedars-Sinai Medical Center

  公开号：EP2882862A2

  公开（公告）日：2015-06-17
• METHODS AND APPARATUSES FOR SURFACE FUNCTIONALIZATION AND COATING OF NANOCRYSTALS
  申请人：Nikoobakht Babak

  公开号：US20150038578A1

  公开（公告）日：2015-02-05

  The present disclosure describes a method and series of compositions for surface functionalization of nanoparticles that eliminates the possibility of ligand loss in alien environments. In particular, the present disclosure provides method and compositions for production of highly-stable surface-functionalized nanorods of noble metals for in-vivo applications as well as use in composite materials.
• [EN] METHIONINE METABOLITES PREDICT AGGRESSIVE CANCER PROGRESSION<br/>[FR] LES MÉTABOLITES DE LA MÉTHIONINE PRÉDISENT LA PROGRESSION D'UN CANCER AGRESSIF
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2014026157A2

  公开（公告）日：2014-02-13

  The invention relates to the use of enzymes, nanorods, and nanoelectronic devices to detect cysteine level in a patient sample and relates to the use of the detected cysteine level to predict cancer recurrence in the patient and to prescribe and/or administer an appropriate therapy to a subject. The invention is directed to systems and methods of detecting cysteine level in a sample from a subject, wherein the systems or methods can further comprise measuring at least one additional parameter, such as PSA level, Gleason score and clinical stage. The invention is directed to systems and methods of predicting the probability of a recurrence of a cancer in a subject, wherein the systems or methods can further comprise measuring at least one additional parameter, such as PSA level, Gleason score and clinical stage. The invention further comprises prescribing and/or administering an appropriate therapy to a subject based on the predicted probability of recurrence.