(2S,3R)-3-tert-Butoxy-2-(2-hydroxy-4-methoxy-benzylamino)-butyric acid | 166881-52-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (2S,3R)-3-tert-Butoxy-2-(2-hydroxy-4-methoxy-benzylamino)-butyric acid
• 英文别名: (2S,3R)-2-[(2-hydroxy-4-methoxyphenyl)methylamino]-3-[(2-methylpropan-2-yl)oxy]butanoic acid
• CAS: 166881-52-3
• 化学式: C₁₆H₂₅NO₅
• 分子量: 311.378
• InChiKey: VVCGTSXJNFBWAW-YGRLFVJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  88
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 (2S,3R)-3-tert-Butoxy-2-(2-hydroxy-4-methoxy-benzylamino)-butyric acid 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 (2R,3R)-3-tert-Butoxy-2-(4-methoxy-2-trimethylsilanyloxy-benzylamino)-butyric acid
  参考文献：
  名称：

  A new approach to Hmb-backbone protection of peptides: Synthesis and reactivity of Nα-Fmoc-Nα-(Hmb)amino acids

  摘要：

  The use of N-Fmoc-N-(Hmb)amino acids for the introduction of the Hmb backbone protection into peptides during solid-phase synthesis is described An efficient two step synthesis of these derivatives is reported and their coupling to the peptide chain is studied. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00303-1
• 作为产物：
  描述：

  O-叔丁基-L-苏氨酸 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 3.0h， 生成 (2S,3R)-3-tert-Butoxy-2-(2-hydroxy-4-methoxy-benzylamino)-butyric acid
  参考文献：
  名称：

  A new approach to Hmb-backbone protection of peptides: Synthesis and reactivity of Nα-Fmoc-Nα-(Hmb)amino acids

  摘要：

  The use of N-Fmoc-N-(Hmb)amino acids for the introduction of the Hmb backbone protection into peptides during solid-phase synthesis is described An efficient two step synthesis of these derivatives is reported and their coupling to the peptide chain is studied. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00303-1

文献信息

• A new approach to Hmb-backbone protection of peptides: Synthesis and reactivity of Nα-Fmoc-Nα-(Hmb)amino acids
  作者：Ernesto Nicolás、Montse Pujades、Jordi Bacardit、Ernest Giralt、Fernando Albericio

  DOI：10.1016/s0040-4039(97)00303-1

  日期：1997.3

  The use of N-Fmoc-N-(Hmb)amino acids for the introduction of the Hmb backbone protection into peptides during solid-phase synthesis is described An efficient two step synthesis of these derivatives is reported and their coupling to the peptide chain is studied. (C) 1997 Elsevier Science Ltd.